In recent years, Micro-Electro-Mechanical System (MEMS) has successfully enabled the development of IPv6 over Low power Wireless Personal Area Network (6LoWPAN). This network is equipped with lowcost, low-power, lightweight and varied functions devices. These devices are capable of amassing, storing, processing environmental information and conversing with neighbouring sensors. These requisites pose a new and interesting challenge for the development of IEEE 802.15.4 together with routing protocol. In this work, 6LoWPAN Routing Protocol with Local Repair Using Bio Inspired Artificial Bee Colony (6RLR-ABC) has been introduced. This protocol supports connection establishment between nodes in an energyefficient manner while maintaining high packet delivery ratio and throughput and minimizing average endto-end delay. This protocol has been evaluated based on increasing generated traffic. The performance of the designed 6RLR-ABC routing protocol has been evaluated compared to 6LoWPAN Ad-hoc On-Demand Distance Vector (LOAD) routing protocol. LOAD protocol has been chosen since it is the most relevant existed 6LoWPANrouting protocol. The simulation results show that the introduced 6RLR-ABC protocol achieves lower packet average end-to-end delay and lower energy consumption compared to LOAD protocol.Additionally,the packet delivery ratio of the designed protocol is much higher than LOAD protocol. The proposed 6RLR-ABC achieved about 39% higher packet delivery ratio and about 54.8% higher throughput while simultaneously offering lower average end-to-end delay and lower average energy consumption than LOAD protocol.