Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

Stener-Victorin, Elisabet; Manti, Maria; Fornes, Romina; Risal, Sanjiv; Lu, Haojiang; Benrick, Anna

doi:10.3390/medsci7080086

Cited by 13 publications

(17 citation statements)

References 70 publications

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“…Male offspring with ancestral DHEA exposure showed lower sperm quality. There is evidence that a significant correlation exists between the prenatal and early postnatal environment of PCOS women and their pregnancy outcomes (24,26). Continuous injection of androgens or their metabolites is commonly used to replicate PCOS-like phenotypes in rodents.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats

Zhang

Dong

et al. 2020

Front. Endocrinol.

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Androgen exposure of female fetuses could be an important factor in the development of polycystic ovary syndrome (PCOS) in subsequent generations. The present study aimed to investigate the transgenerational effects of PCOS on the growth, reproduction, and metabolism of the first-and second-generation offspring in rats. Female F0 rats received excessive dehydroepiandrosterone (DHEA) exposure to establish PCOS or the same amount of vehicle as controls. These F0 females were crossed with normal males to obtain control (C) and DHEA (D) F1 offspring, whereas F2 offspring were obtained by inter-crossing between F1 rats for 4 groups: (1) C♂-C♀; (2) D♂-C♀; (3) C♂-D♀ and (4) D♂-D♀. Compared with control groups, F1 and F2 offspring with ancestral DHEA exposure showed higher body weight with increasing age. In addition, female F1 and F2 offspring with ancestral DHEA exposure exhibited PCOS-like reproductive and metabolic phenotypes, including disrupted estrous cycles and polycystic ovaries, as well as increased serum levels of testosterone, impaired glucose tolerance and widespread metabolic abnormalities. Male offspring with ancestral DHEA exposure exhibited lower quality of sperms. These findings confirm the negative effects of excessive androgen exposure of female fetuses on subsequent generations.

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Section: Discussionmentioning

confidence: 99%

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats

Zhang

Dong

et al. 2020

Front. Endocrinol.

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“…Sexual dysfunction [163] and depression [164] are increasingly coincident sequelae in women with PCOS [21]. Four macaque models of PCOS are potentially of relevance to their developmental origins.…”

Section: Behavioral Pcos-related Traits In Macaque Modelsmentioning

confidence: 99%

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

et al. 2019

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Indian rhesus macaque nonhuman primate models for polycystic ovary syndrome (PCOS) implicate both female hyperandrogenism and developmental molecular origins as core components of PCOS etiopathogenesis. Establishing and exploiting macaque models for translational impact into the clinic, however, has required multi-year, integrated basic-clinical science collaborations. Paradigm shifting insight has accrued from such concerted investment, leading to novel mechanistic understanding of PCOS, including hyperandrogenic fetal and peripubertal origins, epigenetic programming, altered neural function, defective oocytes and embryos, adipogenic constraint enhancing progression to insulin resistance, pancreatic decompensation and type 2 diabetes, together with placental compromise, all contributing to transgenerational transmission of traits likely to manifest in adult PCOS phenotypes. Our recent demonstration of PCOS-related traits in naturally hyperandrogenic (High T) female macaques additionally creates opportunities to employ whole genome sequencing to enable exploration of gene variants within human PCOS candidate genes contributing to PCOS-related traits in macaque models. This review will therefore consider Indian macaque model contributions to various aspects of PCOS-related pathophysiology, as well as the benefits of using macaque models with compellingly close homologies to the human genome, phenotype, development and aging.

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“…The risk of anxiety and depression was significantly increased in patients with PCOS. Relevant research showed that more than 60% of PCOS patients were diagnosed with at least one kind of mental disorder [ 122 ]. The severity of depression, anxiety, obsessive-compulsive disorder, and somatization disorder measured by different scales in PCOS patients was higher than that in women without PCOS [ 123 ].…”

Section: Meditation Stress Reductionmentioning

confidence: 99%

The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism

Jia

Feng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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As a reproductive endocrine disease, polycystic ovary syndrome (PCOS) has influenced billions of women during childbearing age worldwide. Owing to its complex etiology and ambiguous pathogenesis, there is still not a specific method to cure it. Clinical treatments, such as hormone therapy and surgical treatment, have side effects. Therefore, it is essential and urgent to seek alternative treatment to solve these problems. The satisfactory efficacy of complementary and alternative medicine (CAM), such as traditional Chinese medicine (TCM), immunotherapy, medicinal foods, vitamin therapy, diet therapy, psychotherapy, spa, and oxygen therapy, in treating PCOS, has aroused an increasing number of medical workers’ concern and gradually become the mainstream. This paper reviews the application of CAM in the treatment of PCOS, especially from the perspective of TCM. Meanwhile, the limitations of the literature about CAM in the treatment of PCOS are mentioned and analyzed as well.

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Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

Cited by 13 publications

References 70 publications

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism

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