Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach

Pediaditakis, Nicholas

doi:10.4236/jbbs.2012.22030

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diagnosing these phenomena as co-morbidities mask the fact that it is the same disease with its frequent shift in its syndrome. Second, the group gene loci associated with schizophrenia and the other four conditions (i.e., attention-deficit/hyperactivity disorder (ADHD), bipolar affective disorder, obsessive-compulsive disorder (OCD), and incapacitating anxiety) [2] certainly code for the premorbid personalities of the mentioned major mental disorders and not the expression of the disorders themselves, since, the former invariably antedates the latter [3]. Focusing on schizophrenia, each of the variant syndromes of the disorder occurs probabilistically on some The initial expression of the periodic epiphenomena, comprising the major mental disorders-superimposed on the pre-existing "lopsided," temperament, (i.e., premorbid trait) should be considered-at least in the beginning-similar to atrial fibrillation.…”

Section: Methodsmentioning

confidence: 99%

Some Thoughts Regarding the Narrative of the Current Nosological Schema and their Ramifications for Major Mental Disorders with a Focus on Schizophrenia

Pediaditakis¹

2020

OJPsych

Self Cite

View full text Add to dashboard Cite

The current nosological schema for major mental disorders does not capture all the clinical phenomena, especially those being observed longitudinally (i.e., six decades of clinical observations of over eight thousand patients suffering with emotional problems of which three thousands of them suffer from major mental disorders, spanning two to three generations by the author). The objective of this article is to point out that these overlooked in their collective significance phenomena-even though they are noted by the clinicians, are not part of the categorical guidelines of the current schema. They have ramifications for better conceptualizing the road-guide in our future research for these baffling, major mental disorders, including schizophrenia, bipolar affective disorder, obsessive-compulsive disorder (OCD), anxiety, and attention deficit hyperactivity disorder (ADHD), which are sharing a common, neuro-developmental origin.

show abstract

Section: Methodsmentioning

confidence: 99%

Some Thoughts Regarding the Narrative of the Current Nosological Schema and their Ramifications for Major Mental Disorders with a Focus on Schizophrenia

Pediaditakis¹

2020

OJPsych

Self Cite

View full text Add to dashboard Cite

show abstract

“…Actually, all of the aforementioned, clinical expressions manifest themselves as a kind of psychic-Parkinsonism [31] [32], reflecting an abrupt switch from the normal phase of the overall, coordinating mode of brain function, insuring smoothness, elegance and subtlety, to that of a black and white, either-or, and entrained character in their expressions. The normally present, over-all, synchronizing faculty of the expression of all higher mental functions is rarely taken into account.…”

Section: The Significance Of the Overall Synchronizing Mode Of Brain mentioning

confidence: 99%

Revisiting the Major Mental Disorders and Updating the Nosological Schema: A Synthesis

Pediaditakis¹

2016

JBBS

Self Cite

View full text Add to dashboard Cite

Recently, conciliating findings from molecular genetics, evolutionary biology, along with empirical clinical evidence regarding the major mental disorders (MMDs) namely bipolar affective disorder (BPAD), schizophrenia, obsessive compulsive disorder (OCD), the anxieties with depression, autism and attention deficit/hyperactivity disorder (ADHD) all point to a common neural-developmental origin. Genetic loci associated with schizophrenia do not directly lead to the disorder; instead, they code for the expression of lopsided, temperamental, variants in individuals that originate mainly from one part of our human nature which applies also, to the rest of the MMDs. These individuals contribute to the flexibility, robustness, and creative input of our species, concomitantly, they incur vulnerability to the development of a MMD as an evolutionary trade off. MMDs initially, are expressed as periodic epiphenomena on the underlying temperamental extreme variants of brain function. Their expressions tend to become permanent. Underlying, aberrant traits remain unaltered. Their clinical expressions are characterized by "either-or", antithetical substitutes, in addition to co-occurring psychosis. The latter is a common occurrence to other assaults on brain function. Characteristic, "ether-or" symptoms are the result of a disturbed, overall, coordinating property of brain function, normally responsive to the smooth, synchronizing expression of all higher mental faculties. Clinical findings point to the need of modifying the current schema in order to better reflect their collective significance in order to help guide research to a new, more promising direction in elucidating their triggers, development, and mechanisms whereby opening a new horizon for therapy and treatment.

show abstract

An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders

Pediaditakis

2016

TONEUJ

Self Cite

View full text Add to dashboard Cite

Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of major mental disorders (MMDs), which should be considered the result of an evolutionary downside trade off. Temperamental/trait variability, by facilitating choices for individual and group responses, confers robustness flexibility and resilience crucial to success of our species. Extreme temperamental variants, originating evolutionarily from the asocial aspect of human nature, also constitute the premorbid personality of the disorders. The latter create vulnerable individuals out of whom some will develop MMDs but at much higher rate to that of the general population. Significantly, similar temperamental “lopsidedness” enables many of these vulnerable individuals, if intelligent, tenacious, and curious, to be creative and contribute to our survival while some may also develop MMDs. All have a common neural-developmental origin and share characteristics in their clinical expression and pharmacological responses also expressed as mixed syndromes or alternating ones over time. Over-pruning of synaptic neurons may be considered the trigger of such occurrences or conversely, the failure to prevent them in spite of it. The symptoms of the major mental disorders are made up of antithetical substitutes as an expression of a disturbed over-all synchronizing property of brain function for all higher faculties previously unconsidered in their modeling. The concomitant presence of psychosis is a generic common occurrence.

show abstract

Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach

Cited by 3 publications

References 37 publications

Some Thoughts Regarding the Narrative of the Current Nosological Schema and their Ramifications for Major Mental Disorders with a Focus on Schizophrenia

Some Thoughts Regarding the Narrative of the Current Nosological Schema and their Ramifications for Major Mental Disorders with a Focus on Schizophrenia

Revisiting the Major Mental Disorders and Updating the Nosological Schema: A Synthesis

An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders

Contact Info

Product

Resources

About