Origins of medial geniculate body projections to physiologically defined zones of rat primary auditory cortex

Winer, Jeffery A.; Sally, Sharon L.; Larue, David T.; Kelly, Jack B.

doi:10.1016/s0378-5955(98)00217-2

Cited by 93 publications

(91 citation statements)

References 62 publications

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“…We found that most MGB neurons projecting to AI were located in the ventral division (MGBv) as previously described for the rat (Ryugo and Killackey 1974;Winer et al 1999). Similarly, we found that most MGB neurons projecting to VAF were located in the MGBv.…”

Section: Analysis Of Thalamic Input To Ai and Vafsupporting

confidence: 87%

“…This is consistent with previous reports in the cat and primate, although in those species the AI map typically features multiple modules of sharp spectral tuning or nonmonotonic intensity tuning, whereas AI maps in the rat typically featured a single module for each feature (Cheung et al 2001;Philibert et al 2005;Phillips et al 1994;Schreiner and Mendelson 1990;Sutter and Schreiner 1995). Injection of retrograde tracer into the middle-frequency representation of AI yielded a heavy deposit of label in the rostral region of the MGBv and a sparse, scattered distribution of label in the MGBm, as was previously reported in the rat (Kimura et al 2003;Roger and Arnault 1989;Romanski and LeDoux 1993b;Ryugo and Killackey 1974;Winer et al 1999).…”

Section: The Primary Auditory Cortexsupporting

confidence: 76%

“…However, the rostrocaudal position of labeled MGBv neurons was different and was minimally overlapping for injections into the two cortical regions. Injection of CTB into the 8-kHz region of AI and VAF clearly labeled a population of neurons in the lateral region of the MGBv in three cases, in accordance with the approximate lateral-tomedial topography for low-to high-frequency lamina in MGBv (Winer et al 1999). However, the highest density of retrograde-labeled neurons projecting to AI were located 4,920 Ϯ 159 m posterior to bregma.…”

Section: Analysis Of Thalamic Input To Ai and Vafsupporting

confidence: 75%

“…Anatomical tracer studies conducted in the rat confirmed that AI lies in cortical area TEI and receives heavy projections from the ventral division of the medial geniculate body (MGv) into the middle cortical layers (Kimura et al 2003;Roger and Arnault 1989;Romanski and LeDoux 1993b;Winer et al 1999). Electrophysiological recordings within AI describe well-tuned, short-latency responses that exhibit an orderly tonotopic progression of characteristic frequency (CF) from low (ϳ1 kHz) to high (ϳ60 kHz) along a posterior-to-anterior gradient .…”

Section: Introductionmentioning

confidence: 99%

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Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat

Polley

Read²,

Storace³

et al. 2007

Journal of Neurophysiology

302

326

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Section: Analysis Of Thalamic Input To Ai and Vafsupporting

confidence: 87%

Section: The Primary Auditory Cortexsupporting

confidence: 76%

Section: Analysis Of Thalamic Input To Ai and Vafsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat

Polley

Read²,

Storace³

et al. 2007

Journal of Neurophysiology

302

326

View full text Add to dashboard Cite

show abstract

“…In the rat, anatomical evidence for descending pathways from the cortex to lower levels of the auditory system is plentiful (e.g., Faye-Lund 1985;Herbert et al 1991;Weedman and Ryugo 1996;Winer et al 1999). These cortico-fugal pathways have been shown to mediate positive feedback and to strongly modulate activity in both MGB and IC in the bat (Zhang and Suga 1997).…”

Section: Discussionmentioning

confidence: 99%

Role of Mammalian Auditory Cortex in the Perception of Elementary Sound Properties

Talwar

Musial

Gerstein

2001

Journal of Neurophysiology

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Talwar, Sanjiv K., Pawel G. Musial, and George L. Gerstein. Role of mammalian auditory cortex in the perception of elementary sound properties. J Neurophysiol 85: 2350 -2358, 2001. Studies in several mammalian species have demonstrated that bilateral ablations of the auditory cortex have little effect on simple sound intensity and frequency-based behaviors. In the rat, for example, early experiments have shown that auditory ablations result in virtually no effect on the rat's ability to either detect tones or discriminate frequencies. Such lesion experiments, however, typically examine an animal's performance some time after recovery from ablation surgery. As such, they demonstrate that the cortex is not essential for simple auditory behaviors in the long run. Our study further explores the role of cortex in basic auditory perception by examining whether the cortex is normally involved in these behaviors. In these experiments we reversibly inactivated the rat primary auditory cortex (AI) using the GABA agonist muscimol, while the animals performed a simple auditory task. At the same time we monitored the rat's auditory activity by recording auditory evoked potentials (AEP) from the cortical surface. In contrast to lesion studies, the rapid time course of these experimental conditions preclude reorganization of the auditory system that might otherwise compensate for the loss of cortical processing. Soon after bilateral muscimol application to their AI region, our rats exhibited an acute and profound inability to detect tones. After a few hours this state was followed by a gradual recovery of normal hearing, first of tone detection and, much later, of the ability to discriminate frequencies. Surface muscimol application, at the same time, drastically altered the normal rat AEP. Some of the normal AEP components vanished nearly instantaneously to unveil an underlying waveform, whose size was related to the severity of accompanying behavioral deficits. These results strongly suggest that the cortex is directly involved in basic acoustic processing. Along with observations from accompanying multiunit experiments that related the AEP to AI neuronal activity, our results suggest that a critical amount of activity in the auditory cortex is necessary for normal hearing. It is likely that the involvement of the cortex in simple auditory perceptions has hitherto not been clearly understood because of underlying recovery processes that, in the long-term, safeguard fundamental auditory abilities after cortical injury.

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Cells in the posterior thalamus project to both amygdala and temporal cortex: A quantitative retrograde double-labeling study in the rat

2000

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Auditory information from the posterior thalamus reaches the lateral nucleus of the amygdala (LA) by way of two pathways: a direct thalamo-amygdala projection and a polysynaptic thalamo-cortico-amygdala projection. However, the quantitative extent of thalamic neurons that project to the LA or to the auditory association cortex (AAC) is not known. Furthermore, the extent and topographical distribution of bifurcating cells that project to both LA and AAC are also unknown. Therefore, separate tracers were injected into LA and either into all of AAC or within discrete regions of AAC, such as temporal areas TE3 or perirhinal cortex (PRh), and quantitative analyses were performed on labeling within the subregions of the auditory thalamus in rats. Following LA injections, retrogradely labeled cells were most numerous in the posterior intralaminar nucleus (PIN; 48.0% of all labeled thalamic cells), whereas labeled cells following injections of the entire AAC were most numerous in the dorsal division of the medial geniculate nucleus (MGd; 32.9% of all labeled thalamic cells). Following AAC injections localized to only TE3, the MGd again had the majority of labeled cells (35.9%), whereas following AAC injections localized to PRh, the PIN had the most labeled cells (32.8%). Double-labeled cells were found in all the thalamic regions studied and were most commonly observed in the PIN (43.7% of all double-labeled cells following injections into LA and throughout the AAC). The percentage of double-labeled cells as a proportion of either LA-projecting or AAC-projecting cells varied among the thalamic nuclei studied, ranging from 2.9% up to 42.4%. The topographic distribution of double-labeled cells in the thalamic nuclei resembled that of single-labeled cells following LA injections more than single-labeled cells following AAC injection. These findings suggest that double-labeled cells contribute substantially to many of the direct thalamo-amygdala and indirect thalamo-AAC-amygdala projections. Among other functions, these bifurcating cells may help regulate the processing of input to the LA arriving from these two pathways to allow for certain types of plasticity in the LA during fear conditioning.

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Origins of medial geniculate body projections to physiologically defined zones of rat primary auditory cortex

Cited by 93 publications

References 62 publications

Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat

Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat

Role of Mammalian Auditory Cortex in the Perception of Elementary Sound Properties

Cells in the posterior thalamus project to both amygdala and temporal cortex: A quantitative retrograde double-labeling study in the rat

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