Origins of the sympathetic innervation to the nasal-associated lymphoid tissue (NALT): An anatomical substrate for a neuroimmune connection

Marafetti, Lucas E.; Romeo, Horacio E.

doi:10.1016/j.jneuroim.2014.09.003

Cited by 3 publications

(4 citation statements)

References 56 publications

(79 reference statements)

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“…The SCG also conveys the autonomic stress response and contributes to related cardiovascular diseases [45]. It is also part of the neuroimmune connection providing the sympathetic innervation of, e.g., nasal-associated lymphoid tissue (NALT) [46]. Notably, there is also evidence for reducing SPN as part of autonomic dysfunction in Parkinson´s and Lewy-body diseases [47,48].…”

Section: Discussionmentioning

confidence: 99%

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent

Reuss

2021

J. Integr. Neurosci.

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Location and distribution of spinal sympathetic preganglionic neurons projecting to the superior cervical ganglion were investigated in a rodent model organism for photoperiodic regulation, the Djungarian hamster (Phodopus sungorus). Upon unilateral injection of Fluoro-Gold into the superior cervical ganglia, retrograde neuronal tracing demonstrated labeled neurons ipsilateral to the injection site. They were seen in spinal segments C8 to Th5 of which the segments Th1 to Th3 contained about 98% of the labeled cells. Neurons were found in the spinal cord predominantly in the intermediolateral nucleus pars principalis and pars funicularis. At the same time, the central autonomic area and the intercalated region contained only very few labeled cells. In the intermediolateral nucleus, cells often were arranged in clusters, of which several were seen in each spinal segment. Selected sections were exposed to antibodies directed against arginine-vasopressin, neuronal nitric oxide synthase, neuropeptide Y, neurotensin, oxytocin or substance P. It was found that about twothirds of sympathetic preganglionic neurons produced the gaseous neuroactive substance nitric oxide and that few contained small amounts of neuropeptide Y. Fibers of putative supraspinal origin immunopositive for either arginine-vasopressin, neuronal nitric oxide synthase, neuropeptide Y, neurotensin, oxytocin or, in particular, substance P were found in the vicinity of labeled sympathetic preganglionic neurons. These results demonstrate the location of relay neurons for autonomic control of cranial and cardial structures and provide further knowledge on neurochemical properties of sympathetic preganglionic neurons and related structures.

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Section: Discussionmentioning

confidence: 99%

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent

Reuss

2021

J. Integr. Neurosci.

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“…Regardless of how PrP Sc reaches the NALT, it proceeds to progressively accumulate over time, until deposits fill the structure [56]. It is also not clear if there is a mechanism for the transport of PrP Sc from the NALT into the CNS, but sympathetic post-ganglionic fibers have been identified within the NALT that might be a source of neuroinvasion [79]. The cell bodies of these fibers are located in the superior cervical ganglion [79] and are synaptically contacted by sympathetic preganglionic fibers that originate from sympathetic preganglionic neurons located in the intermediolateral cell column of the rostral thoracic spinal cord.…”

Section: The Role Of Lrs Tissues In Prion Pathogenesis Following Nc Exposurementioning

confidence: 99%

“…It is also not clear if there is a mechanism for the transport of PrP Sc from the NALT into the CNS, but sympathetic post-ganglionic fibers have been identified within the NALT that might be a source of neuroinvasion [79]. The cell bodies of these fibers are located in the superior cervical ganglion [79] and are synaptically contacted by sympathetic preganglionic fibers that originate from sympathetic preganglionic neurons located in the intermediolateral cell column of the rostral thoracic spinal cord. As mentioned earlier, there have been no reports of PrP Sc in the superior cervical ganglion following the inhalation of prions into the NC.…”

Section: The Role Of Lrs Tissues In Prion Pathogenesis Following Nc Exposurementioning

confidence: 99%

The Role of the Nasal Cavity in the Pathogenesis of Prion Diseases

Kincaid

2021

Viruses

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Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a class of fatal neurodegenerative diseases caused by the entry and spread of infectious prion proteins (PrPSc) in the central nervous system (CNS). These diseases are endemic to certain mammalian animal species that use their sense of smell for a variety of purposes and therefore expose their nasal cavity (NC) to PrPSc in the environment. Prion diseases that affect humans are either inherited due to a mutation of the gene that encodes the prion protein, acquired by exposure to contaminated tissues or medical devices, or develop without a known cause (referred to as sporadic). The purpose of this review is to identify components of the NC that are involved in prion transport and to summarize the evidence that the NC serves as a route of entry (centripetal spread) and/or a source of shedding (centrifugal spread) of PrPSc, and thus plays a role in the pathogenesis of the TSEs.

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“…As fibras simpáticas cervicais são capazes de modular a resposta imune local e podem agir junto com o sistema NALT (Marafetti et al, 2014).…”

Section: Ige Localunclassified

Produção local de IgE e outros mediadores imunológicos no lavado nasal dos pacientes com rinite alérgica antes e após a realização de imunoterapia específica com o ácaro Dermatophagoides pteronyssinus

Rodrigues¹

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Origins of the sympathetic innervation to the nasal-associated lymphoid tissue (NALT): An anatomical substrate for a neuroimmune connection

Cited by 3 publications

References 56 publications

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent

The Role of the Nasal Cavity in the Pathogenesis of Prion Diseases

Produção local de IgE e outros mediadores imunológicos no lavado nasal dos pacientes com rinite alérgica antes e após a realização de imunoterapia específica com o ácaro Dermatophagoides pteronyssinus

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