Our main purpose in this article is to establish a Gagliardo-Nirenberg type inequality in the critical Sobolev-Morrey space H M the growth order r 1− 1 p as r → ∞. The inequality (GN) implies that the growth order as r → ∞ is linear, which might look worse compared to the case of the critical Sobolev space. Communicated by Hans Triebel. Y. Sawano ( ) J Fourier Anal ApplHowever, we investigate the optimality of the growth order and prove that this linear order is best-possible. Furthermore, as several applications of the inequality (GN), we shall obtain a Trudinger-Moser type inequality and a Brézis-Gallou ët-Wainger type inequality in the critical Sobolev-Morrey space.