Orlistat in Combination Therapy of Obesity and Type 2 Diabetes

Мкртумян, А. М.; Бирюкова, Е. В.

doi:10.21518/2079-701x-2017-3-68-74

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Основными направлениями лечения ГЭРБ являются изменение образа жизни, медикаментозное лечение и хирургическое вмешательство. Известно, что нормализация веса улучшает и/или устраняет ГЭРБ и астму, лечение ГЭРБ улучшает контроль над астмой, хотя и не приводит к потере веса, и хотя эти заболевания не изучались в совокупности, выявление и лечение этих заболеваний оказывает положительное влияние на контроль над каждым из них [76,[80][81][82][83][84].…”

Section: гастроэзофагеальная рефлюксная болезнь бронхиальная астма ож...unclassified

Gastroesophageal reflux disease, obesity, bronchial asthma: simple combination or complex interaction

Druk,

Usacheva,

Nadey

et al. 2024

jour

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Gastroesophageal reflux disease (GERD) continues to be one of the most common diseases in primary health care. In recent years, the presence of several diseases in the same patient at the same time has been widely discussed. An increase in persons suffering from several chronic diseases is associated with a deterioration in the quality of life, a high risk of hospitalization and mortality, and taking into account the presence of co/poly/multimorbidity is necessary for decision-making when developing a patient management strategy in primary health care. Studies on GERD, obesity and bronchial asthma have shown that there are common and bidirectional mechanisms in the development of these diseases. And, there are many gaps in understanding these relationships, it is important to identify concomitant diseases, since they can be the cause of resistance to therapy, to form an unfavorable prognosis of their course.

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Section: гастроэзофагеальная рефлюксная болезнь бронхиальная астма ож...unclassified

Gastroesophageal reflux disease, obesity, bronchial asthma: simple combination or complex interaction

Druk,

Usacheva,

Nadey

et al. 2024

jour

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The Impact of Stress on Pathogenetic Mechanisms of Obesity (Systematic Review)

Ткаченко

Bagro

2020

FMEP

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Obesity is reaching the scale of a pandemic and is growing progressively every year. Taking into account the introduction of quarantine in many countries of the world associated with COVID-19, alarge number of patients are in a state of constant stress, hypodynamics, hypoxemia, which contributes to the prevalence of this nosology. Under such conditions, there is a need for a detailed analysis of the impact of stress and other factors on the pathogenetic links in the development of obesity, determines the relevance of our study and the need to find more effective preventive measures in the practice of family medicine.The objective: is to analyse the pathogenetic mechanisms of obesity under the influence of stress and other factors using systematic analysis of literature data.Materials and methods. A systematic review of literature sources in the field of obesity and its pathogenetic aspects was conducted by keywords: pathogenesis of obesity, overveight, stress, hypothalamic-pituitary-adrenal system, orexin, serotonin for the period 2015–2020. The search was carried out mainly in PubMed and Cochrane databases. The bibliosemantic method and the method of systematic analysis were used.Results. According to the results of searches in the PubMed and Cochrane databases, 58131 sources were found by keywords, from which 29 most relevant research goals were selected, including: 16 systematic reviews, 2 meta-analyzes, 3 multicenter data and 8 cohort studies. It is established that despite the diversity of pathogenetic aspects of obesity, adipose tissue is an endocrine-active organ that changes the functional state of many organs and systems, leads to metabolic and hormonal changes, led primarily by disbalance of the hypothalamic region, which is responsible for somatoform and hormonal disorders, and for the body’s protective reactions on exposition of many orexogenic factors.Conclusion. A crucial point in the practice of a family doctor, which will help to effectively prevent the development of obesity and its noninfectious and infectious complications, is to study all possible risk factors, their complex interaction at all levels of pathogenetic changes. Taking into account the influence of stress factors on the hypothalamic region, which is one of the key links in the pathogenesis of metabolic and somatoform changes, will help to find more effective approaches to the correction of overweight.

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Обучение Пациента С Сахарным Диабетом На Фоне Избыточной Массы Тела Или Ожирения В Центрах Первичной Медико-Санитарной Помощи

Тулянцева¹,

Величко²,

Лагода³

2021

Рецепт

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В XXI веке проблемы сахарного диабета и избыточной массы тела или ожирения приобрели масштабы эпидемии. Каждые 13–15 лет количество пациентов с диабетом 2-го типа удваивается, до 2040 года прогнозируют увеличение числа пациентов до 642 млн лиц, а до 2045 – до 700 млн. Аналогичным образом продолжает расти распространенность избыточной массы тела или ожирения во всем мире. Около 1,9 млрд людей в мире имеют избыточную массу тела, а 650 млн – ожирение. Поскольку диабет – это хроническое, прогрессирующее заболевание, с которым пациенту придется существовать всю жизнь, оно требует длительной, пожизненной терапии при участии самого пациента. С 1998 года образование пациентов официально включено ВОЗ в стратегию лечения диабета и стало неотъемлемой частью организации помощи пациентам, которые живут с диабетом, во многих странах. На кафедре семейной медицины Одесского национального медицинского университета создана и успешно функционирует«Школа диабета и избыточной массы тела», основной целью которой является предоставление информационной поддержки взрослым и детям, которые живут с диабетом, избыточной массой тела или ожирением, а также их родным. In the 21st century, the problems of diabetes and overweight or obesity have reached epidemic proportions. Every 13–15 years, the number of patients with type 2 diabetes doubles; by 2040, the number of patients is predicted to increase to 642 million, and by 2045 – to 700 million. Similarly, the prevalence of overweight or obesity continues to grow worldwide. About 1.9 billion people in the world are overweight and 650 million are obese. Since diabetes is a chronic, progressive disease, with which the patient will have to live their whole life, it requires long-term, lifelong therapy with the patient’s participation. Since 1998, patient education has been formally incorporated into the WHO’s diabetes management strategy by WHO and has become an integral part of the organizationof care for patients with diabetes in many countries. The Department of Family Medicine of Odessa National Medical University has established and successfully operates the “School of Diabetes and Overweight”, the main goal of which is to provide information support for adults and children who live with diabetes, overweight or obesity, as well as their families.

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Orlistat in Combination Therapy of Obesity and Type 2 Diabetes

Cited by 3 publications

References 24 publications

Gastroesophageal reflux disease, obesity, bronchial asthma: simple combination or complex interaction

Gastroesophageal reflux disease, obesity, bronchial asthma: simple combination or complex interaction

The Impact of Stress on Pathogenetic Mechanisms of Obesity (Systematic Review)

Обучение Пациента С Сахарным Диабетом На Фоне Избыточной Массы Тела Или Ожирения В Центрах Первичной Медико-Санитарной Помощи

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