ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice

Qin, Zhen; Wan, Jingjing; Sun, Yang; Wang, Peng‐Yuan; Su, Ding‐Feng; Hong, Lei; Liu, Xia

doi:10.3389/fphar.2016.00302

Cited by 29 publications

(20 citation statements)

References 43 publications

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“…Further studies have demonstrated that ORM binds to C–C chemokine receptor type 5 (CCR5) on muscle cells and activates AMPK, thus promoting glycogen storage and enhancing muscle endurance, and representing a positive feedback mechanism for resisting fatigue and maintaining homeostasis. 60 , 61 Modulation of the level of ORM and CCR5 signaling may be a novel strategy for the management of muscle fatigue.…”

Section: Factors That Affect Muscle Contraction and Fatiguementioning

confidence: 99%

Muscle fatigue: general understanding and treatment

et al. 2017

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Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments.

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Section: Factors That Affect Muscle Contraction and Fatiguementioning

confidence: 99%

Muscle fatigue: general understanding and treatment

et al. 2017

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“… 9 In addition, most of the studies described above were conducted in Western countries where the prevalence of obesity is high. Recently, Qin et al 10 have demonstrated that ORM activates AMP-activated protein kinase (AMPK) in skeletal muscle, which led to the activation of glycogen synthase and subsequent glycogen storage. As AMPK is important for glucose uptake and glycogen storage in the myocytes 11 and skeletal muscle is responsible for the majority of glucose disposal, 12 we aimed to examine whether ORM is associated with postchallenge glycemia in non-obese Japanese women and whether these associations, if any, depend on fat mass and distribution, insulin resistance (IR) and insulin secretion.…”

Section: Introductionmentioning

confidence: 99%

Association of serum orosomucoid with 30-min plasma glucose and glucose excursion during oral glucose tolerance tests in non-obese young Japanese women

Tsuboi

Minato

Yano

et al. 2018

BMJ Open Diab Res Care

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ObjectiveInflammatory markers are elevated in insulin resistance (IR) and diabetes. We tested whether serum orosomucoid (ORM) is associated with postload glucose, β-cell dysfunction and IR inferred from plasma insulin kinetics during a 75 g oral glucose tolerance test (OGTT).Research design and methods75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30–120 min period in 168 non-obese Japanese women (aged 18–24 years). OGTT responses, serum adiponectin and high-sensitivity C reactive protein (hsCRP) were cross-sectionally analyzed by analysis of variance and then Bonferroni’s multiple comparison procedure. Stepwise multivariate linear regression analyses were used to identify most important determinants of ORM.ResultsOf 168 women, 161 had normal glucose tolerance. Postload glucose levels and the area under the glucose curve (AUCg) increased in a stepwise fashion from the first through the third ORM tertile. In contrast, there was no or modest, if any, association with fat mass index, trunk/leg fat ratio, adiponectin, hsCRP, postload insulinemia, the Matsuda index and homeostasis model assessment IR. In multivariable models, which incorporated the insulinogenic index, the Matsuda index and HOMA-IR, 30 min glucose (standardized β: 0.517) and AUCg (standardized β: 0.495) explained 92.8% of ORM variations.ConclusionsElevated circulating orosomucoid was associated with elevated 30 min glucose and glucose excursion in non-obese young Japanese women independently of adiposity, IR, insulin secretion, adiponectin and other investigated markers of inflammation. Although further research is needed, these results may suggest a clue to identify novel pathways that may have utility in monitoring dysglycemia within normal glucose tolerance.

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“…Increased levels of serum AGP are probably a manifest of systemic inflammation associated with COPD. However, AGP has anti-fatigue action on skeletal muscle (51) and is also shown to suppress SR stress as loss of AGP increases SR stress related response (52). Thus, the small, albeit non-significant decrease in serum AGP in advanced COPD complies with muscle weakness and SR stress in these participants.…”

Section: Discussionmentioning

confidence: 94%

SR stress in locomotor muscles of patients with chronic obstructive pulmonary disease

Qaisar

Qayyum

Muhammad

2020

Preprint

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Background The potential contribution of chronic dysregulation of sarcoplasmic reticulum (SR) protein homeostasis (a condition called SR stress) to skeletal muscle loss is poorly understood. We investigated the degree of activation of SR stress in locomotor muscles of patients with chronic obstructive pulmonary disease (COPD), a respiratory disease with systemic manifestations. Methods We analyzed the markers of SR stress and associated pathologies in vastus lateralis muscles of 60-65 years old male healthy controls and patients with mild (COPD stages 1 & 2) and advanced (COPD stages 3 & 4) COPD (N = 6-8 / group). Results Skeletal muscle proteins expressions of GRP94, BiP, CHOP and ATF were significantly elevated in advanced COPD (≈53%, ≈3.6 fold, ≈3.5 fold and ≈3.2 fold, respectively) compared with healthy controls. The expression of downstream markers of SR stress including apoptosis, inflammation and autophagy was increased, while the maximal activity of SR Ca2+ ATPase (SERCA) enzyme was significantly reduced in advanced COPD (≈41%) than healthy controls. Single muscle fiber diameter and cytoplasmic domain per myonucleus were significantly smaller (≈14% and 13%, respectively) in patients with advanced COPD than healthy controls. These changes in SR dysfunction were accompanied by substantially elevated levels of global oxidative stress including lipid peroxidation and mitochondrial ROS production. Conclusion Taken together, our data suggests that the muscle weakness in advanced COPD is in part driven by elevated SR stress and its pathological consequences. The data provided can lead to potential therapeutic interventions of SR dysfunction for muscle detriment in COPD.

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ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice

Cited by 29 publications

References 43 publications

Muscle fatigue: general understanding and treatment

Muscle fatigue: general understanding and treatment

Association of serum orosomucoid with 30-min plasma glucose and glucose excursion during oral glucose tolerance tests in non-obese young Japanese women

SR stress in locomotor muscles of patients with chronic obstructive pulmonary disease

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