Orofacial antinociceptive effect of Mimosa tenuiflora (Willd.) Poiret

Magalhães, Francisco Ernani Alves; Batista, Francisco Lucas Alves; Serpa, Ohanna F.; Moura, Luiz Francisco Wemmenson Gonçalves; Lima, Maria da Conceição L.; Silva, Ana Raquel A. da; Guedes, Maria Izabel Florindo; Santos, Sacha Aubrey Alves Rodrigues; Oliveira, Breytiner Amaro de; Nogueira, Andressa Barros; Barbosa, Talita Matias; Holanda, Dayse Karine Rodrigues; Damasceno, Marina B.M.V.; Melo, José de Maria A. de; Barroso, Lana Karine Vasconcelos; Campos, Adriana Rolim

doi:10.1016/j.biopha.2017.11.001

Cited by 22 publications

(8 citation statements)

References 56 publications

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“…It is noteworthy that the importance of the data demonstrated for the compound fluid extract, which presented similar results in gastroprotective activity to other extracts. Also, the absence of toxicity points to the potential use of FEI, FES and FEL in phytotherapeutic preparations, since the samples showed non toxic to HEK-293 cells will not be toxic to humans (Magalhães et al, 2018;Fadeyi et al, 2013). These results corroborate with findings of Viana et al (1995), which demonstrated that hydroalcoholic extract of inner bark is destitute of toxicity.…”

Section: Discussionsupporting

confidence: 86%

Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão - A conservationist proposal for the species

Galvão

Braz-Filho

Canuto

et al. 2018

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 86%

Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão - A conservationist proposal for the species

Galvão

Braz-Filho

Canuto

et al. 2018

Journal of Ethnopharmacology

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“…Several plants have been used for compounds extraction with bioactivity, specifically to be evaluated as healing agents, among them we can find Mimosa tenuiflora . This plant has compounds such as alkaloids, chalcones, steroids, polyphenols, polysaccharides and terpenoids, which are known to promote fibroblast division and promote signaling pathways aimed at inhibiting inflammation and pain 4 – 6 . It is also known that M. tenuiflora extract has a powerful bactericidal and fungicidal effect.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

Martínez-Higuera

Rodríguez-Beas

Villalobos-Noriega

et al. 2021

Sci Rep

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In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.

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“…Phenotypic consequences of ELS can originate from molecular changes such as DNA methylation (Romens et al, 2015; Turecki and Meaney, 2016) and altered gene transcription (Vazquez et al, 1996), which have effects at the endocrine level, including dysregulation of stress hormones (O’Mahony et al, 2009; Magalhaes et al, 2018). The hypothalamic-pituitary-adrenal (HPA) axis is particularly susceptible to stress-driven alterations (Vazquez et al, 1996; van der Knaap et al, 2014; Romens et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cross-Generational Transmission of Early Life Stress Effects on HPA Regulators and Bdnf Are Mediated by Sex, Lineage, and Upbringing

Coley

Demaestri

Ganguly

et al. 2019

Front. Behav. Neurosci.

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Early life stress (ELS) is a potent developmental disruptor and increases the risk for psychopathology. Various forms of ELS have been studied in both humans and rodents, and have been implicated in altered DNA methylation, gene transcription, stress hormone levels, and behavior. Although recent studies have focused on stress-induced epigenetic changes, the extent to which ELS alters HPA axis function and stress responsivity across generations, whether these effects are sex-specific, and how lineage interacts with upbringing to impact these effects, remain unclear. To address these points, two generations of rodents were utilized, with the first generation subjected to ELS via maternal separation, and the second to a balanced cross-fostering paradigm. We hypothesized that ELS would disrupt normative development in both generations, manifesting as altered methylation and expression of genes associated with stress signaling pathways (Nr3c1, Nr3c2, and Bdnf), blunted corticosterone (CORT), and anxiety-like behaviors. Additionally, we expected deficits in the second generation to be modulated by caretaking environment and for the pattern of results to differ between the sexes. Results suggest that direct exposure to ELS leads to sex-specific effects on gene regulation and HPA functioning in adulthood, with maternal separation leading to increases in Bdnf methylation in both sexes, decreases in Bdnf expression in females, and decreases in Nr3c1 methylation in males, as well as blunted CORT and less anxiety-like behavior in females. These alterations converged with caretaking to impart perturbations upon the subsequent generation. Across sex, ELS lineage led to decreased methylation of Nr3c1, and increased methylation of Bdnf. In fostered animals, upbringing by a previously stressed mother interacted with offspring lineage to impact methylation of Nr3c1 and Bdnf. Upbringing was also implicated in altered anxiety-like behavior in males, and baseline CORT levels in females. Such effects may correspond with observed alterations in maternal behavior across groups. In conclusion, ELS conferred enduring sex-specific alterations, both first-hand and trans -generationally via lineage and upbringing. Importantly, lineage of cross-fostered pups was sufficient to normalize or disturb maternal behavior of foster-dams, an observation requiring further elucidation. These results have implications for multi-generational effects of ELS in humans and may motivate early interventions.

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Orofacial antinociceptive effect of Mimosa tenuiflora (Willd.) Poiret

Cited by 22 publications

References 56 publications

Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão - A conservationist proposal for the species

Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão - A conservationist proposal for the species

Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

Cross-Generational Transmission of Early Life Stress Effects on HPA Regulators and Bdnf Are Mediated by Sex, Lineage, and Upbringing

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