Orofacial granulomatosis successfully treated with mycophenolate mofetil

Antonyan, Albert S; Peña-Robichaux, Venessa; McHargue, Chauncey

doi:10.1016/j.jaad.2014.01.848

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…The therapeutic effect of a low dose of methotrexate (5‐25 mg weekly) is believed to be because of immunomodulation through increased levels of adenosine, and is hence largely devoid of the cytotoxic and/or anti‐proliferative effects achieved with higher doses Mycophenolate mofetil has been reported as beneficial, in the management of lip swelling, in case reports both in combination with corticosteroids or tacrolimus and as a sole agent . However, no formal trials have been conducted. …”

Section: Management Of Orofacial Granulomatosismentioning

confidence: 99%

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The mouth in inflammatory bowel disease and aspects of orofacial granulomatosis

Hullah

Escudier

2019

Periodontology 2000

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Inflammatory bowel disease has a wide range of possible oral manifestations, many of which overlap with those seen in other conditions, including orofacial granulomatosis. The precise etiology remains unclear, as is the exact relationship between orofacial granulomatosis and Crohn's disease. Overall, there is growing evidence that orofacial granulomatosis and oral Crohn's disease are distinct clinical disorders with optimal management requiring a multidisciplinary approach with input from appropriate specialists in oral medicine, gastroenterology, allergy, dietetics, and clinical psychology. This review details the etiopathogenesis, clinical presentation, epidemiology, extra‐intestinal, and oral manifestations of inflammatory bowel disease and orofacial granulomatosis. It also assesses the current role of investigations in the diagnosis of orofacial granulomatosis and critically reviews the available evidence in relation to medical and surgical interventions for the condition, and its relationship to Crohn's disease.

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Section: Management Of Orofacial Granulomatosismentioning

confidence: 99%

“…The patient described was initially commenced on Mycophenolate mofetil 500 mg orally twice‐daily, and showed clinical improvement after 1 mo and near complete resolution after 6 mo . Therapy was continued with sustained benefit and no demonstrable toxicity at 1 y …”

Section: Management Of Orofacial Granulomatosismentioning

confidence: 99%