Orofacial manifestations of SAPHO syndrome: a systematic review of case reports

Ferreira-Vilaca, Clémence; Mendes, Léonor Costa; Campana, Sophie-Caroline; Bailleul‐Forestier, Isabelle; Audouin-Pajot, Christine; Esclassan, Rémi; Canceill, Thibault

doi:10.1007/s10067-020-05084-6

Cited by 7 publications

(6 citation statements)

References 69 publications

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“…Inflammatory cutaneous and articular manifestations have been found among SAPHO syndrome patients 23 . The main characteristics of the dermatologic manifestations are neutrophilic pustular dermatoses, 24 including pustular psoriasis, palm plant impetigo (PPP), psoriasis vulgaris, severe acne, or hidradenitis suppurativa 9,25,26 . Chronic inflammatory aseptic osteitis is the central feature of SAPHO bone lesions, manifested by tenderness, pain, and changes in bone structure 7,27 .…”

Section: Discussionmentioning

confidence: 99%

“…23 The main characteristics of the dermatologic manifestations are neutrophilic pustular dermatoses, 24 including pustular psoriasis, palm plant impetigo (PPP), psoriasis vulgaris, severe acne, or hidradenitis suppurativa. 9, 25,26 Chronic inflammatory aseptic osteitis is the central feature of SAPHO bone lesions, manifested by tenderness, pain, and changes in bone structure. 7,27 Moreover, the routine blood test showed that the inflammatory markers hs-CRP and ESR were significantly increased in SAPHO syndrome samples.…”

Section: Discussionmentioning

confidence: 99%

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An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

Wang,

Gong,

Xia

et al. 2024

Int J of Rheum Dis

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BackgroundSAPHO syndrome is recognized as a rare entity with damage to skin and bones due to inflammation. Currently, the treatment for SAPHO syndrome is still a challenge in clinical practice. In this study, an integrated transcriptomics and network pharmacology approach was applied to explore the therapeutic effect and mechanism of Wang‐Bi tablet (WBT) on SAPHO syndrome.MethodsThe main components of WBT and their targets, as well as the targets of SAPHO syndrome, were collected from databases. Network visualization was performed using Cytoscape software. The GO and KEGG enrichment analysis was executed by David dataset. Then, the molecular mechanism of WBT improving SAPHO syndrome was validated by transcriptomics of peripheral blood neutrophils in SAPHO syndrome. Finally, the above results were validated by molecular docking.ResultsThe Network Pharmacology results showed there are 152 core targets for WBT treatment on SAPHO syndrome. RNA‐seq data showed 442 differentially expressed genes (DEGs) in peripheral blood neutrophils of SAPHO patients. Intriguingly, NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway were included in the enrichment results of network pharmacology and RNA‐seq. Moreover, we verified that the core components of WBT have good affinity with the core targets of NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway by molecular docking.ConclusionsThis study illustrated that the possible mechanisms of WBT against SAPHO syndrome may be related to NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway, and further experiments are needed to prove these predictions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

Wang,

Gong,

Xia

et al. 2024

Int J of Rheum Dis

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“…As shown in our case, odontologists play an important role in such patients. A review on cases also suggested that a multidisciplinary medical team including rheumatologists, surgeons, dermatologists and odontologists would be crucial in treatment of such patients 6 …”

Section: Discussionmentioning

confidence: 99%

Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome with mandibular involvement: Would surgical operation help?

Liu

Cao

et al. 2022

Int J of Rheum Dis

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Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is defined by a series of lesions including synovitis, pustulosis, hyperostosis and osteitis. Osteoarticular disorder is one of the main characteristic features of SAPHO syndrome and typically involves the anterior chest wall, Mandibular involvements occurs in 2%-10% of SAPHO patients and are mainly located in the posterior ramus. 1 Currently, there are no guidelines for treatment of such patients; despite its rarity, the interest in mandibular involvement in SAPHO treatment is rising.SAPHO with mandibular osteitis usually arises as obvious swelling and pain in the posterior mandibular body and ramus, 1-3 few patients would present with temporomandibular joint (TMJ) involvement. A study showed that most primary chronic osteomyelitis patients undergo surgery. 3 In our previous study, we found that 7.7%(2/14) of mandibular-involved SAPHO patients underwent unilateral mandible resection. 4 However, due to rarity of such patients and lack of a related study, the impact of such surgery remains unclear.Here, we present a SAPHO patient with mandibular osteitis who underwent a series of mandibular resection surgeries and repeated relapses. This unique combination of events suggests that surgical

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“…Most of the reports concerning handicapped patients also concern a low number of subjects, limiting the applicability of care recommendations 11 . The only way to increase the global level of evidence of these case reports or case series is to perform systematic reviews specifically dedicated to case reports 13 . Thus, knowing the variability in the care of handicapped patients, the aim of this study is, first, to report a clinical case of dental restoration in a patient with special needs and then to determine, through a systematic review, different therapeutic solutions that can be launched for anterior restorations in disabled people.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic solutions for anterior restorations in disabled patients: Systematic review and case report

Abouzeir,

Gurgel‐Georgelin,

Diemer

et al. 2023

Special Care in Dentistry

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IntroductionTreating anterior restorations is a real challenge for a dentist and conventional protocols are not always applicable. The aim of this study is to determine different therapeutic to conducting anterior restorations in disabled people.Case reportWe begin by presenting the case of a 23‐year‐old, handicapped man, who was brought in consultation to compensate for the loss of the left upper central incisor (#21).Materials and methodsWe then performed a systematic literature review in December 2022, in accordance with the PRISMA guidelines. The publications, on three databases, dealing with dental treatments on disabled people were selected whether they were clinical studies or case reports.ResultsIn the end, 14 publications were included. Most of the treatments described in the studies (n = 10; 71.43%) concern people aged under 19. The patients present different types of handicaps with various degrees of severity and the oral diseases described are as heterogeneous as the handicaps retrieved.DiscussionIt is therefore difficult to make common treatment recommendations for all these variable profiles and situations. Most of patients in this study are very young, so there is a need for preventive and therapeutic care as earlier as possible, to preserve the vitality of their teeth and dental occlusion.

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Orofacial manifestations of SAPHO syndrome: a systematic review of case reports

Cited by 7 publications

References 69 publications

An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome with mandibular involvement: Would surgical operation help?

Therapeutic solutions for anterior restorations in disabled patients: Systematic review and case report

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