Orofacial Pain—Part I

Sarlani, Eleni; Balciunas, B. A.; Grace, Edward G.

doi:10.1097/00044067-200507000-00007

Cited by 28 publications

(6 citation statements)

References 80 publications

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“…There is considerable variability in prevalence, cause, and treatment of these disorders. More detailed reviews on neuropathic pains classification, etiology, and pathophysiology can be found elsewhere 12,67,68…”

Section: Neuropathic Painmentioning

confidence: 99%

Orofacial pain management: current perspectives

Romero‐Reyes¹,

Uyanik²

2014

JPR

201

121

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Some of the most prevalent and debilitating pain conditions arise from the structures innervated by the trigeminal system (head, face, masticatory musculature, temporomandibular joint and associated structures). Orofacial pain (OFP) can arise from different regions and etiologies. Temporomandibular disorders (TMD) are the most prevalent orofacial pain conditions for which patients seek treatment. Temporomandibular disorders include a number of clinical problems that involve the masticatory musculature, the temporomandibular joint (TMJ) or both. Trigeminal neuropathic pain conditions can arise from injury secondary to dental procedures, infection, neoplasias, or disease or dysfunction of the peripheral and/or central nervous system. Neurovascular disorders, such as primary headaches, can present as chronic orofacial pain, such as in the case of facial migraine, where the pain is localized in the second and third division of the trigeminal nerve. Together, these disorders of the trigeminal system impact the quality of life of the sufferer dramatically. A multidisciplinary pain management approach should be considered for the optimal treatment of orofacial pain disorders including both non-pharmacological and pharmacological modalities.

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Section: Neuropathic Painmentioning

confidence: 99%

Orofacial pain management: current perspectives

Romero‐Reyes¹,

Uyanik²

2014

JPR

201

121

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“…Orofacial pain is often complicated by psychological factors and may require multidisciplinary therapy. The medical history and physical examination, laboratory testing, and imaging findings enable selection of the optimal choice of therapy [ 1 2 ]. It has been shown that the sympathetic nervous system is usually involved in various pain disorders such as postherpetic neuralgia, complex regional pain syndrome (CRPS), and orofacial pain [ 3 4 5 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of stellate ganglion block in orofacial pain: a mini review

Jeon

2016

J Dent Anesth Pain Med

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Orofacial pain is a common complaint of patients that causes distress and compromises the quality of life. It has many etiologies including trauma, interventional procedures, nerve injury, varicella-zoster (shingles), tumor, and vascular and idiopathic factors. It has been demonstrated that the sympathetic nervous system is usually involved in various orofacial pain disorders such as postherpetic neuralgia, complex regional pain syndromes, and atypical facial pain. The stellate sympathetic ganglion innervates the head, neck, and upper extremity. In this review article, the effect of stellate ganglion block and its mechanism of action in orofacial pain disorders are discussed.

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“…Animal models of neuropathic pain following peripheral nerve injury result in behavioral signs of thermal hyperalgesia and mechanical allodynia in the affected limbs [e.g., 3, 15, 19]. Most animal models of trigeminal nerve injury involve constriction, ischemic injury or transection of the infraorbital or inferior alveolar nerves [7, 11–13, 24] or the mental nerve [9, 10, 16–18, 23].…”

Section: Introductionmentioning

confidence: 99%

Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models

Boucher

Carstens

Sawyer

et al. 2013

Neuroscience Letters

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Many patients suffer from trigeminal neuralgia and other types of orofacial pain that are poorly-treated, necessitating preclininal animal models for development of mechanisms-based therapies. The present study assessed capsaicin avoidance and other nocifensive behavioral responses in three models of orofacial nerve injury in rats: chronic construction injury (CCI) of the mental nerves, partial tight ligation of mental nerves, and CCI of lingual nerves. We additionally investigated if nerve injury resulted in enhanced capsaicin-evoked activation of neurons in trigeminal caudalis (Vc) or nucleus of the solitary tract (NTS) based on expression of Fos-like immunoreactivity (FLI). Mental nerve CCI resulted in an enhancement of capsaicin avoidance in a two-bottle preference paradigm, while neither mental nerve injury produced thermal hyperalgesia or mechanical allodynia. CCI of lingual nerves did not affect capsaicin avoidance. Counts of FLI in Vc were significantly higher in the lingual sham and mental nerve CCI groups compared to mental shams; FLI counts in NTS did not differ among groups. Mental nerve CCI may have induced central sensitization of chemical nociception since increased capsaicin avoidance was accompanied by greater activation of Vc neurons in response to oral capsaicin.

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Orofacial Pain—Part I

Cited by 28 publications

References 80 publications

Orofacial pain management: current perspectives

Orofacial pain management: current perspectives

Therapeutic potential of stellate ganglion block in orofacial pain: a mini review

Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models

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