Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Buttà, Michela; Serra, Nicola; Panzarella, Vera; Fasciana, Teresa Maria Assunta; Campisi, Giuseppina; Capra, Giuseppina

doi:10.3390/vaccines11091466

Cited by 7 publications

(1 citation statement)

References 54 publications

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“…All these updates could potentially help untangle controversial topics, such as the in uence of Human Papillomavirus (HPV) infection on male fertility. The risk of contracting HPV at least once in a lifetime is about 80% for any sexually active person [5][6][7] . More than 200 different HPV genotypes have been identi ed, divided into high-risk (hrHPV) and low-risk HPV (lrHPV), depending on the likelihood of inducing the development of neoplastic lesions.…”

Section: Introductionmentioning

confidence: 99%

Human Papilloma Virus and Male Infertility: An Analysis Following World Health Organization 2021 Guidelines

Notari,

Buttà,

Serra

et al. 2024

Preprint

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Male infertility is a complex and multifaceted issue, which can be influenced by multiple environmental and pathological factors. In this context, the impact of Human papillomavirus (HPV) male infection remains controversial. The introduction of new WHO 2021 evaluation criteria, i.e. DNA fragmentation index (DFI), slow and rapid progressive motility, could provide additional information about this debated correlation. In this regard, 121 semen samples of male partners of HPV-positive women attending In Vitro Fertilization (IVF) were evaluated following WHO 2021 and HPV-DNA test. Comparing HPV-negative and positive samples for rapid progressive motility and slow progressive motility showed significantly different results (p = 0.0018, p = 0.0004), contrary to what observed for total progressive motility. Regarding sperm DFI, only high-risk HPV infections appear to affect DNA integrity. In addition, the correlation between the different semen parameters has brought out a statistically significant correlation between midpiece morphological defects and rapid progressive motility in the HPV-positive group. We can conclude that WHO 2021 provides additional information about the impact of HPV on male infertility. Moreover, the correlation between HPV positivity, midpiece defects and a higher rapid progressive motility opens new lines of research that may help unravel the issues surrounding the role of HPV in compromising sperm quality.

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Section: Introductionmentioning

confidence: 99%

Human Papilloma Virus and Male Infertility: An Analysis Following World Health Organization 2021 Guidelines

Notari,

Buttà,

Serra

et al. 2024

Preprint

View full text Add to dashboard Cite

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Prevalence and genotype distribution of HPV combined with cervical pathological results in women from Sichuan, China: A cross‐sectional study based on post‐vaccination period 2019 to 2023

Mo,

Ye,

et al. 2024

Cancer Medicine

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BackgroundHuman papillomavirus (HPV) screening and vaccination exert efficacy in controlling the progression of cervical cancer. Thus, examinations into HPV prevalence, age‐stratified specificity, genotype distribution, and their correlation with pathological outcomes can furnish robust evidence for customizing high‐quality population screening and management.MethodsA cohort of 17,923 women attending clinics in the Jintang area, Sichuan, from January 2019 through August 2023 were enrolled in the study. Genotyping of HPV was conducted using real‐time polymerase chain reaction (RT‐PCR). The epidemiology and the relationship between HPV infection and histologic/cytologic abnormalities were subjected to analysis.ResultsHPV infection was identified in 4387 women. The outpatient group exhibited a significantly higher HPV infection rate compared to the healthy examination group (26.5% vs. 17.5%, p < 0.05). The distribution of infection rates across different age groups exhibited a U‐shaped pattern, with the highest infection rate in the group ≤20 years of age, succeeded by those >60 years of age. The 31–40 age group demonstrated the lowest prevalence of infection, but upon infection, its prevalence of the precancerous lesion CIN2‐3 reached a maximum of 29.0%, constituting a novel finding. The most prevalent genotype was HPV52, followed by HPV16, 58, 53, 68, and 18. In the cytologic and histologic abnormalities group, the most common types were HPV52, 16, and 58. HPV16 predominantly appeared in high‐grade intraepithelial neoplasia and carcinoma in situ, constituting over 60% of cases. While HPV type 52 was not individually detected in cervical cancer cases. And some other non‐vaccine‐covered HPV subtypes also showed high prevalence in Sichuan. The single infection rates of NH9‐HPV (high‐risk HPV subtypes covered by the non‐nine‐valent vaccine) in CIN2‐3 and cervical cancer patients were 6.5% and 2.6%, respectively. Among them, HPV51, HPV53, HPV59, and HPV35 exhibited a significant preponderance, which even higher than HPV45 and HPV31 covered by the nine‐valent vaccine types. And in NL9‐HPV (low‐risk HPV subtypes covered by the non‐nine‐valent vaccine), HPV42 accounted for the highest percentage in CIN2‐3. A similar decreasing trend was observed in annual infection rates in the healthy examination population and in the 31–40 and 51–60 age groups, while the ≤20 age group showed an increase. Regarding type‐specificity, HPV16 and HPV58 exhibited the most rapid declines.ConclusionThis study furnishes the latest insights into the characteristics of HPV infection rate, age distribution, and genotype prevalence in Sichuan.

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Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection

Chen,

Nie,

Ran

et al. 2024

Journal of Medical Virology

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Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervical exfoliated cells to examine the infection rate and the clinical characteristics of patients with single HPV73 infection, and to investigate the association of viral load, persistent infection, and pathogenicity. The positive rate of HPV73 among women tested was approximately 0.14% (609/435 072). Among 214 HPV73 single infection cases, the number of patients with normal cytology, cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and cervical cancer were 182, 24, 5, 1, and 1, respectively. Follow‐up data showed that 14.29% (3/21) of CIN1 patients developed to higher‐grade lesions, with 3.73% (5/134) of normal patients progressed to CIN. The viral load in the CIN group was significantly higher than that in the normal group (p = 0.001), and the viral load in the persistent infection group was significantly higher than that of the viral‐clearance group (p < 0.001). HPV73 single infection can lead to cervical cancer, with relatively low pathogenicity. And high viral load is a crucial factor in its persistent infection and pathogenicity.

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Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Cited by 7 publications

References 54 publications

Human Papilloma Virus and Male Infertility: An Analysis Following World Health Organization 2021 Guidelines

Human Papilloma Virus and Male Infertility: An Analysis Following World Health Organization 2021 Guidelines

Prevalence and genotype distribution of HPV combined with cervical pathological results in women from Sichuan, China: A cross‐sectional study based on post‐vaccination period 2019 to 2023

Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection

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