Oropharyngeal carcinoma related to human papillomavirus

Mehanna, Hisham M.; Grégoire, Vincent; Jones, Terence M.; Ang, K. Kian

doi:10.1136/bmj.c1439

Cited by 110 publications

(90 citation statements)

References 10 publications

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“…In the UK alone a 51% increase in male oral and oropharyngeal squamous cell carcinoma is mainly attributed to the rise in Human Papillomavirus (HPV) related cancers [1]. In Scotland, incidence rates are particularly high [2].…”

mentioning

confidence: 99%

Predictors of quality of life in head and neck cancer survivors up to 5 years after end of treatment: a cross-sectional survey

Wells

Swartzman

Lang

et al. 2015

Support Care Cancer

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Abstract:Purpose This study aimed to assess quality of life (QoL) in head and neck cancer (HNC) survivors, and determine factors predictive of poor QoL in the first five years after the end of treatment. Methods A cross-sectional survey, including the Quality of Life in Adult Cancer Survivors (QLACS) measure, was sent to HNC survivors in three Scottish health regions, with responses linked to routinely collected clinical data. Independent sample t-tests, ANOVAs, Pearson correlations and multiple hierarchical regressions were used to explore associations between and to determine the contribution made by demographic, lifestyle and clinical factors to predicting 'generic' and 'cancer-specific' quality of life. Results 280 patients (65%) returned questionnaires. After adjustment, multivariate analysis showed that younger age, lower socio-economic status, unemployment and selfreported comorbidity independently contributed to poorer generic and cancer-specific quality of life. In addition to these factors, having had a feeding tube or a diagnosis of oral cavity cancer were independently predictive of poorer cancer-specific quality of life. Conclusions Socio-economic factors and co-morbidity are important predictors of QoL in HNC survivors. These factors and the detrimental long-term effects of feeding tubes need Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporationfurther attention in research and practice.

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confidence: 99%

Predictors of quality of life in head and neck cancer survivors up to 5 years after end of treatment: a cross-sectional survey

Wells

Swartzman

Lang

et al. 2015

Support Care Cancer

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“…Tonsil and oropharyngeal cancers increased in male predominance over the last 30 years, despite a decline in smoking, which may be linked to the decreasing proportion of HPV(-) cancers; while changes in sexual activity may be reflected in increasing proportion of HPV(+) cancers [20]. Recently, HPVassociated OSCC represents about 60% of OSCC cases compared to 40% in the previous decade [22]. In the USA, Sweden, Finland and Czech Republic an increasing incidence of OSCC has been observed during the last decade [23][24][25][26].…”

Section: Epidemiological Data Of Head and Neck Carcinomas And Hpv Invmentioning

confidence: 99%

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2014

Oncotarget

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Human papillomaviruses (HPVs)Human papillomaviruses (HPVs) are small doublestranded DNA viruses that comprise a heterogeneous family consisting of more than 130 different HPV types [1]. Different HPV types have been detected in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa and can cause a wide range of infections, including common warts, genital warts, recurrent respiratory papillomatosis, low-grade and high-grade squamous intraepithelial lesions (SILs), anal cancer, vaginal cancer and cervical cancer. Based on their association with cervical cancer, HPV types are classified as high-risk 18, 31, 33, 35,39,45,51,52,56,58,59,68, 30, 34,53,66,67,69,70,73,82,85) [2]. Evidence of the potential role of HPV in other tumor types has been shown, as well [3][4][5][6][7][8]. High-risk HPV types contribute significantly to viral associated neoplasms, accounting for approximately 600,000 cases (5%) of cancers worldwide annually [9]. In particular, HPV-16 accounts for approximately 50% of cervical carcinomas and more than 90% of HPV(+) carcinomas of the oropharynx (and the other ano-genital sites). Low-risk HPVs have been associated with benign warts of oral and urogenital epithelium in adults as well as children and they are only rarely found in malignant

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“…Within the UK, there has been a 51% increase in oral and oropharyngeal squamous cell carcinoma in men between 1989 and 2006, from 7 per 100,000 to 11 per 100,000 [38].…”

Section: Oral and Pharyngeal Cancermentioning

confidence: 99%

Regional differences in incidence and mortality trends in cancers of the larynx, thyroid, oral cavity and pharynx in England and Scotland: 1975-2002

Olaleye¹,

Siddiq²,

Ekrikpo³

et al. 2013

OJEpi

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There has been an increase in incidence of oral and pharyngeal cancer in the UK especially among males with higher rates in Scotland. However mortality has increased in Scotland and reduced in England. Thyroid cancer incidence has increased in the UK especially among females with higher rates in Scotland. Mortality has reduced in both regions. Laryngeal cancer among males has increased in incidence particularly in Scotland with a decline in incidence in England. Mortality has reduced significantly in England among males but increased in Scotland. Conclusions: In the UK, Scotland has higher incidence rates of HNC compared with England. Mortality has reduced in England from all the HNC sub-sites but has increased in Scotland for laryngeal, oral & pharynxgeal cancers. Although socioeconomic deprivation and its relation to higher alcohol and tobacco consumption have been highlighted as drivers, further studies are required.

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Oropharyngeal carcinoma related to human papillomavirus

Abstract: Incidence is increasing rapidly, with implications for prognosis and policy

Cited by 110 publications

References 10 publications

Predictors of quality of life in head and neck cancer survivors up to 5 years after end of treatment: a cross-sectional survey

Predictors of quality of life in head and neck cancer survivors up to 5 years after end of treatment: a cross-sectional survey

Untitled

Regional differences in incidence and mortality trends in cancers of the larynx, thyroid, oral cavity and pharynx in England and Scotland: 1975-2002

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