Oropharyngeal control of drinking in rats.

Blass, Elliott M.; Jobaris, Russell; Hall, W. G.

doi:10.1037/h0077268

Cited by 27 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to postabsorptive signals, ingestion is influenced by preabsorptive signals from the oral cavity (e.g., taste, swallowing) and the stomach (e.g., distension), as well as by local osmoreceptor signals arising from the liver. Numerous studies have focused on such preabsorptive signals associated with NaCl intake (1,4,15,22,25,35). However, only a few studies have examined the effect of early dietary NaCl conditions on responses to preabsorptive signals, and those studies focused on taste.…”

Section: Discussionmentioning

confidence: 99%

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats

Curtis

Krause

Wong

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

We examined body fluid regulation by weanling (21-25 days) and adult (>60 days) male rats that were offspring of dams fed chow containing either 0.1, 1, or 3% NaCl throughout gestation and lactation. Weanling rats were maintained on the test diets until postnatal day 30 and on standard 1% NaCl chow thereafter. Ad libitum water intake by weanlings was highest in those fed 3% NaCl and lowest in those fed 0.1% NaCl. Adult rats maintained on standard NaCl chow consumed similar amounts of water after overnight water deprivation or intravenous hypertonic NaCl (HS) infusion regardless of early NaCl condition. Moreover, baseline and HS-stimulated plasma Na(+) concentrations also were similar for the three groups. Nonetheless, adult rats in the early 3% NaCl group consumed more of 0.5 M NaCl after 10 days of dietary Na(+) deprivation than did rats in either the 1% or 0.1% NaCl group. Interestingly, whether NaCl was consumed in a concentrated solution in short-term, two-bottle tests after dietary Na(+) deprivation or in chow during ad libitum feeding, adult rats in the 3% NaCl group drank less water for each unit of NaCl consumed, whereas rats in the 0.1% NaCl group drank more water for each unit of NaCl consumed. Thus gestational and early postnatal dietary NaCl levels do not affect stimulated water intake or long-term body fluid regulation. Together with our previous studies, these results suggest that persistent changes in NaCl intake and in water intake associated with NaCl ingestion reflect short-term behavioral effects that may be attributable to differences in NaCl taste processing.

show abstract

Section: Discussionmentioning

confidence: 99%

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats

Curtis

Krause

Wong

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…When thirsty rats drank IS instead of water, however, no change in pVP or pOT was observed (21). Thus the concentration of the fluid that rats consume, not its volume, seems to be the critical variable in providing early inhibitory signals (3,5). Furthermore, vagotomized rats (23,25), capsaicin-treated rats (11), and rats with lesions of the AP/NTS (12,14) all drank much more water than control rats did in response to various thirst stimuli, as if they were not receiving an early satiety signal.…”

Section: Discussionmentioning

confidence: 99%

Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads

Stricker

Callahan

Huang

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Cerebral osmoreceptors mediate thirst and neurohypophyseal secretion stimulated by increases in the effective osmolality of plasma (P(osmol)). The present experiments determined whether an intragastric load of hypertonic saline (ig HS; 0.5 M NaCl, 4 ml) would potentiate these responses before induced increases in P(osmol) in the general circulation could be detected by cerebral osmoreceptors. Adult rats deprived of water overnight and then given intragastric HS consumed much more water in 15-30 min than rats given either pretreatment alone, even though systemic P(osmol) had not yet increased significantly because of the gastric load. In other rats pretreated with an intravenous infusion of 1 M NaCl (2 ml/h for 2 h), plasma levels of vasopressin and oxytocin were considerably elevated 15 and 25 min after intragastric HS treatment, whereas systemic P(osmol) was not increased further. These and other findings are consistent with previous reports that hepatic portal osmoreceptors (or Na(+) receptors) stimulate thirst and neurohypophyseal hormone secretion in euhydrated rats given gastric NaCl loads and indicate that these effects are potentiated when animals are dehydrated.

show abstract

“…The rat, which is a relatively slow drinker, also shows sham drinking Blass, Jobaris, & Hall, 1976). It should be noted, however, that because of its small size, the rat is not as suitable as the dog, sheep, or monkey for this type of experi-ment.…”

Section: Discussionmentioning

confidence: 99%

Drinking in the rhesus monkeys: Peripheral factors.

Maddison¹,

Wood²,

Rolls³

et al. 1980

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

Rhesus monkeys prepared with chronic cannulae implanted in the stomach and duodenum were water deprived for 22.5 hr. With both cannulae closed, a mean of 137 ml was drunk within a 60-min period. When ingested water drained freely from an open gastric cannula, continuous drinking far in excess (878 ml mean intake) of normal occurred. Sham drinking also exceeded (634 ml mean intake) normal when ingested water drained through an open duodenal cannula. This pattern of continuous sham drinking indicates that oropharyngeal stimulation is not sufficient alone, or together with the passage of water through the stomach and the initial part of the duodenum, to terminate drinking. Duodenal infusions of water (25-100 ml) slowed or stopped gastric sham drinking in a dose-dependent fashion, but equivalent infusions of isotonic saline were without effect. Thus, pre-or postabsorptive signals at or beyond the level of the intestine distal to the site of the duodenal cannula are probably important for the termination of drinking in the rhesus monkey

show abstract

Oropharyngeal control of drinking in rats.

Cited by 27 publications

References 21 publications

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats

Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads

Drinking in the rhesus monkeys: Peripheral factors.

Contact Info

Product

Resources

About