Orosomucoid Content of Pleural and Peritoneal Effusions

In order to discriminate between benign and malignant effusions, the value of carcinoembryonic antigen (CEA), alpha1‐acidglycoprotein (AGP), alpha‐fetoprotein (AFP), phosphohexose isomerase (PHI), and beta2‐microglobulin (B2M) has been estimated in serous effusions in a group of 106 patients, 30 with a malignant and 76 with a benign effusion. Mean CEA and AGP levels in malignant effusions were significantly higher than in benign effusions; no significant differences of mean PHI, AFP and B2M levels of benign and malignant effusions were found. CEA level estimations were useful for confirming malignancy in 27% of malignant effusions but in only 7.5% of all effusions, and AGP and PHI for excluding it in 37.5 and 36.0% of all effusions, respectively. With the combination of CEA with AGP or PHI, a correct diagnosis was achieved in only 45 and 44% of all effusions, respectively. The combination of AFP or B2M with CEA, AGP or PHI did not improve the discriminative value for differentiating malignant and benign effusions. Cancer 50:1783–1788, 1982.

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Diagnostic value of tumoral markers in serous effusions. Carcinoembryonic antigen, alpha1-acidglycoprotein, alpha-fetoprotein, phosphohexose isomerase, and Beta2-microglobulin

Martínez-Vea

Gatell

Segura

et al. 1982

Cancer

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Cancer serum index: A useful nonspecific test as a parameter in multimodality screening and assessment of patients with cancer of the prostate

et al. 1981

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A satisfactory, simple test for screening and monitoring of patients with prostatic cancer is still being sought. We suggest the use of a nonspecific test in combination with other tests. The ratio of two serum proteins (alpha 1 acid glycoprotein [AGP] and prealbumin [PAB]), may be useful markers for a cancer serum index (CSI). By separating serum components by gradient polyacrylamide gel electrophoresis, staining and quantitating these proteins by scanning densitometry, and dividing the area of AGP by that of PAB, indices can be obtained. In a test of sera from 450 patients with prostatic cancer, other urologic problems, and normal controls, CSIs of 360 sera presently decoded were found to be: (Formula: see text). The CSI should prove highly valuable when used in combination with selected prostatic cancer tests.

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Serum glycoproteins in the liver diseases IV. Alpha-1 acid glycoprotein level in liver cirrhosis

Arima

Motoyama²,

Yamamoto

et al. 1977

Gastroenterol Jpn

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Circulating alpha-1 acid glycoprotein level in cirrhotic patients was determined by radioimmunoassay, and was compared to the ones in normal subjects and chronic active hepatitis with sublobular necrosis. Serum alpha-1 acid glycoprotein levels in liver cirrhosis (p less than 0.001) and chronic active hepatitis with sublobular necrosis (p less than 0.02) were significantly reduced comparing to the normal subjects, although any statistically significant difference was not observed between the formers. In liver cirrhosis, thie serum alpha-1 acid glycoprotein level correlated negatively with serum albumin concentration but neither with serum alpha-1 globulin fraction nor with Indocyanine green clearance rate.

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Orosomucoid Content of Pleural and Peritoneal Effusions

Cited by 13 publications

References 13 publications

Diagnostic value of tumoral markers in serous effusions. Carcinoembryonic antigen, alpha1-acidglycoprotein, alpha-fetoprotein, phosphohexose isomerase, and Beta2-microglobulin

Diagnostic value of tumoral markers in serous effusions. Carcinoembryonic antigen, alpha1-acidglycoprotein, alpha-fetoprotein, phosphohexose isomerase, and Beta2-microglobulin

Cancer serum index: A useful nonspecific test as a parameter in multimodality screening and assessment of patients with cancer of the prostate

Serum glycoproteins in the liver diseases IV. Alpha-1 acid glycoprotein level in liver cirrhosis

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