Orosomucoid is an independent predictor of prognosis in chronic heart failure

Abstract

Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.

Obscurin and Clusterin Elevation in Serum of Acute Myocardial Infarction Patients

“…[28][29][30][31][32][33][34][35][36][37][38] Transthyretin, hemoglobin subunit alpha, beta, antithrombin III, serum amyloid P-component, fibrinogen α, ß, γ, alpha-1-acid glycoprotein 1 and 2, apolipoprotein A-II, and serotransferrin are relatively highly abundant proteins in human serum and therefore already known biomarkers for cancer, inflammation, cardiac hypertrophy, and heart failure. [28][29][30][31][32][33][34][35][36][39][40][41] Some proteins are known as muscle or cardiac muscle components, such as complement C-4A, C3, obscurin, and titin. 34,35,39,40 We calculated point for screened biomarker candidates with three criteria: First, qualitatively identified number of cases.…”

“…Alpha-1-acid glycoprotein 1 is an acute-phase protein with increased expression in inflammatory conditions or cancer. [28][29][30] Clusterin is a serum protein that protects cardiomyocytes and inhibits complement systems. [31][32][33] There are contradictory results about the elevation or decrease in the level of serum.…”

“…Twelve proteins among 23 were reported with acute inflammation, heart failure, thrombosis, and cardiac diseases . Transthyretin, hemoglobin subunit alpha, beta, antithrombin III, serum amyloid P‐component, fibrinogen α, ß, γ, alpha‐1‐acid glycoprotein 1 and 2, apolipoprotein A‐II, and serotransferrin are relatively highly abundant proteins in human serum and therefore already known biomarkers for cancer, inflammation, cardiac hypertrophy, and heart failure . Some proteins are known as muscle or cardiac muscle components, such as complement C‐4A, C3, obscurin, and titin …”

“…Alpha‐1‐acid glycoprotein 1 is an acute‐phase protein with increased expression in inflammatory conditions or cancer . Clusterin is a serum protein that protects cardiomyocytes and inhibits complement systems .…”

Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression

“…ORM exhibits many biological activities, including modulating immunity, binding and carrying drugs, maintaining the capillary barrier and acting as a disease marker. 17 The role of ORM in cancer, 18 , 19 , 20 cardiovascular diseases 21 , 22 and energy metabolism 23 was revealed recently. We previously reported that ORM was significantly elevated in the sera, liver and muscle tissues of fatigued rodents (for example, sleep-deprivation, forced swimming and treadmill-running models) and the sera of chronic fatigue syndrome patients.…”