Extreme weather events are one of the biggest dangers posed by climate breakdown. As the temperatures increase, droughts and desertification will render whole regions inhospitable to agriculture. At the same time, other regions might suffer significant crop losses due to floods. Usually, regional food shortages can be covered by surpluses from elsewhere on the planet. However, the climate breakdown could trigger sustained food supply disruptions globally. Therefore, it is necessary to develop more stress-resilient crop alternatives by both breeding new varieties and promoting underutilized crop species (orphan crops). The articles in this special issue cover responses of staple crops and orphan crops to abiotic stresses relevant under the climate breakdown, such as heat, water, high salinity, nitrogen, and heavy metal stresses. This information will certainly complement a toolkit that can help inform, support, and influence the design of measures to deal with the climate crisis.