Orphanin-FQ/Nociceptin (OFQ/N) Modulates the Activity of Suprachiasmatic Nucleus Neurons

Allen, Charles N.; Jiang, Zhengxuan; Teshima, Koji; Darland, Tristan; Ikeda, Masayuki; Nelson, Cole S.; Quigley, Denise I.; Yoshioka, Tohru; Allen, Richard B.; Rea, Michael A.; Grandy, David K.

doi:10.1523/jneurosci.19-06-02152.1999

Cited by 65 publications

(48 citation statements)

References 53 publications

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“…We also identified certain genes that are known to play a role in rhythm regulation in the SCN or other tissues in rodents. For example, OPRL1 (also known as nociception receptor) is an opiate receptor that is strongly expressed in the mouse SCN where it binds nociception/orphanin FQ, which suppresses 88% of SCN neurons (41). Moreover, OPRL1 activation down-regulates PER2 in the SCN and accelerates reentrainment of rhythms following a shift in the light-dark cycle (42).…”

Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

238

219

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With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here, we used a previously described time-of-death analysis to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex [Brodmann’s area 11 (BA11) and BA47]. Expression levels were determined by microarray analysis in 146 individuals. Rhythmicity in expression was found in ∼10% of detected transcripts (P < 0.05). Using a metaanalysis across the two brain areas, we identified a core set of 235 genes (q < 0.05) with significant circadian rhythms of expression. These 235 genes showed 92% concordance in the phase of expression between the two areas. In addition to the canonical core circadian genes, a number of other genes were found to exhibit rhythmic expression in the brain. Notably, we identified more than 1,000 genes (1,186 in BA11; 1,591 in BA47) that exhibited age-dependent rhythmicity or alterations in rhythmicity patterns with aging. Interestingly, a set of transcripts gained rhythmicity in older individuals, which may represent a compensatory mechanism due to a loss of canonical clock function. Thus, we confirm that rhythmic gene expression can be reliably measured in human brain and identified for the first time (to our knowledge) significant changes in molecular rhythms with aging that may contribute to altered cognition, sleep, and mood in later life.

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Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

238

219

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“…OFQ cells are present in the preoptic area, anterior hypothalamus, and arcuate nucleus of the hypothalamus of the rat (3) and human (4). Functionally, OFQ has been implicated in a variety of systems including pain (5), anxiety (6), cardiovascular function (7), food intake (8), circadian rhythms (9), and cognition (10). There is also evidence that OFQ may play a role in neuroendocrine function: intracerebroventricular delivery of OFQ in the rat stimulates GH and prolactin (11,12) and has been reported to both stimulate (13) and inhibit (14) corticosterone secretion.…”

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confidence: 99%

Orphanin FQ: Evidence for a Role in the Control of the Reproductive Neuroendocrine System

et al. 2007

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Orphanin FQ (OFQ), also known as nociceptin, is a member of the endogenous opioid peptide family that has been functionally implicated in the control of pain, anxiety, circadian rhythms, and neuroendocrine function. In the reproductive system, endogenous opioid peptides are involved in the steroid feedback control of GnRH pulses and the induction of the GnRH surge. The distribution of OFQ in the preoptic area and hypothalamus overlaps with GnRH, and in vitro evidence suggests that OFQ can inhibit GnRH secretion from hypothalamic fragments. Using the sheep as a model, we examined the potential anatomical colocalization between OFQ and GnRH using dual-label immunocytochemistry. Confocal microscopy revealed that approximately 93% of GnRH neurons, evenly distributed across brain regions, were also immunoreactive for OFQ. In addition, almost all GnRH fibers and terminals in the external zone of the median eminence, the site of neurosecretory release of GnRH, also colocalized OFQ. This high degree of colocalization suggested that OFQ might be functionally important in controlling reproductive endocrine events. O RPHANIN FQ (OFQ), also known as nociceptin, is a member of the family of endogenous opioid peptides, which also includes ␤-endorphin, enkephalins, and dynorphin (1). Whereas sharing some homology with dynorphin, OFQ does not exhibit appreciable binding affinity for classical opioid receptors (1, 2); rather it functions as an endogenous ligand for the opioid receptor like (ORL)-1 receptor (1). OFQ cells are present in the preoptic area, anterior hypothalamus, and arcuate nucleus of the hypothalamus of the rat (3) and human (4). Functionally, OFQ has been implicated in a variety of systems including pain (5), anxiety (6), cardiovascular function (7), food intake (8), circadian rhythms (9), and cognition (10). There is also evidence that OFQ may play a role in neuroendocrine function: intracerebroventricular delivery of OFQ in the rat stimulates GH and prolactin (11, 12) and has been reported to both stimulate (13) and inhibit (14) corticosterone secretion. Sinchak et al. (15) have shown that OFQ delivered into the ventromedial nucleus facilitates lordosis in female rats in a dose-dependent manner. However, there has been relatively little attention to the possible role of OFQ in reproductive neuroendocrine function, specifically in the control of GnRH secretion.GnRH neurons, and their projections to the median eminence, control the secretion of pituitary LH and thus comprise the final common pathway for the neuroendocrine control of reproduction (16). Endogenous opioid peptides are important regulators of the GnRH system, controlling both the preovulatory surge (17) and pulsatile secretion (18) of GnRH. OFQ has been shown to inhibit forskolin-induced GnRH secretion in a dose-dependent manner from rat hypothalamic fragments (19). OFQ cells in the preoptic area and anterior hypothalamus overlap the site of a majority of GnRH perikarya (20 -22). In addition, OFQ fibers and ORL-1 receptors are present in high abund...

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“…3. On the other hand, there is a report that nociceptin causes a regulation of biological rhythm, such as light-induced phase advances (Allen et al, 1999). However, there was no significant advance or delay of active phase and changes in dark ratio, suggesting that nociceptin in vivo has little effect on biological rhythm under natural conditions with a 12-h dark cycle.…”

Section: ) Whereas Mopmentioning

confidence: 87%

Circadian-Dependent Learning and Memory Enhancement in Nociceptin Receptor-Deficient Mice with a Novel KUROBOX Apparatus Using Stress-Free Positive Cue Task

Nagai¹,

Kurokawa²,

Takeshima³

et al. 2007

J Pharmacol Exp Ther

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Using the novel apparatus KUROBOX, learning and memory behaviors, as well as various parameters of movement activity, were reevaluated in mice deficient for nociceptin/orphanin FQ receptor (NOP Ϫ/Ϫ mice) or -opioid receptor (MOP Ϫ/Ϫ mice). This method has the advantages that no handling procedures are required throughout the experiments performed over 3 days, positive cue paradigms are used without water or shock stress, and the method does not disturb the nocturnal habit of mice. NOP Ϫ/Ϫ mice displayed a significant enhancement of learning and memory under stress-free conditions, but there were no changes in the various physical and psychological parameters of movement activity (nest stay ratio, distance moved, speed and angle in the movement) and biological rhythm that were measured. Enhancement of nocturnal learning was observed during the first 12-h dark cycle, and enhancement of memory was observed at the beginning of the second dark cycle in NOP Ϫ/Ϫ mice. In contrast, MOP Ϫ/Ϫ mice showed no significant change in learning and memory behaviors or in physical and psychological parameters of movement activity, except for speed, MOP Ϫ/Ϫ mice showed a significant decrease in speed of movement. Thus, the KUROBOX apparatus provides a useful alternative method to evaluate learning and memory activity under the more physiological conditions. In addition, this apparatus has an advantage that various physical and psychological parameters of movement activity affecting learning and memory behavior are also evaluated at the same time.

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Orphanin-FQ/Nociceptin (OFQ/N) Modulates the Activity of Suprachiasmatic Nucleus Neurons

Cited by 65 publications

References 53 publications

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Orphanin FQ: Evidence for a Role in the Control of the Reproductive Neuroendocrine System

Circadian-Dependent Learning and Memory Enhancement in Nociceptin Receptor-Deficient Mice with a Novel KUROBOX Apparatus Using Stress-Free Positive Cue Task

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