During orthodontic treatment, pain is a subjective experience influenced by several factors. Orthodontic patients consume analgesics at different rates to alleviate this pain. Correlations between orthodontic pain and analgesic consumption were analyzed. Predictive factors to analgesics consumption were not statistically analyzed. This study was conducted to identify the predictive factors for analgesic consumption after initiation of orthodontic treatment with fixed appliances. Two hundred and eighty-six patients involved in this study kept a seven-day diary in which they recorded pain intensity (using a 0–10 numerical rating scale), analgesic consumption, localization of pain, pain triggers, and pain characteristics. Univariable analyses identified potential predictive factors: age, gender, pain intensity, pain localization, pain while chewing, pain at rest, night pain, headache, pulsating pain, sharp pain, dull pain, and tingling. Logistic regression was conducted to create a model that could predict analgesic consumption. Multivariate analyses demonstrated that analgesic consumption was increased by increased age, increased intensity of pain, and presence of a headache. Overall, the model explained 33% of analgesic requirement variability. Age, intensity of pain, and headache proved to be predictors of analgesic consumption. Knowledge of such factors may help clinicians identify orthodontic patients who will consume analgesics on their own.