Orthodontic treatment of patients using bisphosphonates: A report of 2 cases

Rinchuse, Donald J.; Sosovicka, Mark; Robison, Janet M.; Pendleton, Ryan

doi:10.1016/j.ajodo.2006.11.002

Cited by 67 publications

(47 citation statements)

References 13 publications

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“…Indeed, inhibition of orthodontic tooth movement, rather than ONJ, has been described in four cases with a bisphosphonate exposure history. 51,52 Whilst extraction spaces are preferably closed by bodily movement, root tipping was observed. Caution is advised with invasive diode laser therapy, miniscrew skeletal anchorage devices, mucosal trauma from retainers, orthognathic surgery and tooth extraction.…”

Section: Orthodonticsmentioning

confidence: 99%

“…Caution is advised with invasive diode laser therapy, miniscrew skeletal anchorage devices, mucosal trauma from retainers, orthognathic surgery and tooth extraction. It has also been proposed that patients discontinue their bisphosphonate therapy for a period of time prior to orthodontic treatment, 51 but this would require further investigation before implementation as these drugs have a terminal half-life of approximately 10 years.…”

Section: Orthodonticsmentioning

confidence: 99%

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A review of the clinical implications of bisphosphonates in dentistry

Borromeo

Tsao

Darby

et al. 2010

Australian Dental Journal

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Bisphosphonates are drugs that suppress bone turnover and are commonly prescribed to prevent skeletal related events in malignancy and for benign bone diseases such as osteoporosis. Bisphosphonate associated jaw osteonecrosis (ONJ) is a potentially debilitating, yet poorly understood condition. A literature review was undertaken to review the dental clinical implications of bisphosphonates. The present paper briefly describes the postulated pathophysiology of ONJ and conditions with similar clinical presentations. The implications of bisphosphonates for implantology, periodontology, orthodontics and endodontics are reviewed. Whilst bisphosphonates have potential positive applications in some clinical settings, periodontology particularly, further clinical research is limited by the risk of ONJ. Prevention and management are reviewed, including guidelines for reducing cumulative intravenous bisphosphonate dose, cessation of bisphosphonates prior to invasive dental treatment or after ONJ development, and the use of serum beta-CTX-1 in assessing risk. In the context of substantial uncertainty, the implications of bisphosphonate use in the dental clinical setting are still being determined.

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Section: Orthodonticsmentioning

confidence: 99%

Section: Orthodonticsmentioning

confidence: 99%

A review of the clinical implications of bisphosphonates in dentistry

Borromeo

Tsao

Darby

et al. 2010

Australian Dental Journal

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“…Little is known concerning orthodontic care at this point, but it is anticipated that adult orthodontic care is feasible and safe but may be slowed or even stopped during the first 3 years of oral bisphosphonate exposure due to the antiresorptive (antiosteoclastic) effects of the bisphosphonate. 38,39 Dental implant placements are also likely safe and will osseointegrate during this period. 40 However, informed consent should be provided as to an increased risk for implant failure or osteonecrosis about the implants once the oral bisphosphonate exposure exceeds 3 years.…”

Section: Preventionmentioning

confidence: 99%

Oral Bisphosphonate-Induced Osteonecrosis: Risk Factors, Prediction of Risk Using Serum CTX Testing, Prevention, and Treatment

Marx

Cillo

Ulloa

2007

Journal of Oral and Maxillofacial Surgery

695

553

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“…Dat bisfosfonaten de orthodontische verplaatsing van gebitselementen belemmeren, werd bevestigd door enkele gepubliceerde klinische casussen (Schwartz, 2005;Rinchuse et al, 2007;Zahrowski, 2007). Bij intraveneus gebruik werd de orthodontische verplaatsing van gebitselementen niet slechts vertraagd, maar zelfs volledig geblokkeerd.…”

Section: Thema: Medische Aspecten Van De Mondzorgunclassified