Orthogonal Multiple Click Reactions for Macromolecular Design

Abstract

In this article, we first examine the classical click reactions and new members (or candidates) to the click chemistry family involving multicomponent reactions (MCRs) utilized in synthetic polymer chemistry. The pros and cons of MCRs are described in the way of click chemistry philosophy. Subsequently, updated click combinations implemented to the synthesis of macromolecular structures are presented in two tables starting from double toward multiple. Moreover, combinations of click reactions with MCRs are presented comprehensively.

Polyether Synthesis through Reductive Etherification Reaction Strategy

“…Various reactions fit the DOI: 10.1002/macp.202300063 above mentioned criteria: copper-catalyzed azide-alkyne cycloaddition (CuAAC), Diels-Alder (DA)/retro-DA, thiolene/thiol-yne, Michael addition, oxime ligation, thiol-bromo, amine/thiol-epoxy, and to some extent multicomponent reactions. [1][2][3][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] These reactions, particularly CuAAC and DA, have immediately found extensive implementations in synthetic polymer chemistry. [3] The reductive etherification reaction (RER) is a convenient pathway to achieve ethers from aldehyde and ketone carbonyls through organosilane-based reducing agents in conjunction with Bronsted or Lewis acids (Scheme 1).…”