Orthogonally clickable hyperbranched polymers: effect of reactant size and polarity on core-functionalization of peripherally jacketed HBPs

Abstract

Using an orthogonally clickable strategy, the accessibility of internal allyl groups in jacketed HBPs, bearing either PEG or docosyl peripheral segments, was shown to depend both on the size and relative polarity of the reactant thiol.

Hyperbranched polymers: growing richer in flavours with time

“…However, by using clickable HBPs, improved core-shell-type HBPs could readily be prepared. Fully PEGylated HB polyesters have been prepared via click reactions of HB polyesters carrying either allyl 53 or propargyl 54 ester groups on their periphery. Thus, clickable HBPs serve as excellent scaffolds for derivatisation with desired segments, to modulate their solubility properties.…”

Amphiphilic Polymer Hydrogel‐supported Catalysts: Tuning the Accessibility to the Catalytic Site by Molecular Jacketing

“…[24][25][26] Some years ago, we reported strategies to prepare peripherally "clickable" hyperbranched polyesters (HBPs), carrying either propargyl or allyl groups; further we demonstrated that they can be quantitatively functionalized to install a variety of moieties using azide-alkyne and thiol-ene click reaction, respectively. [27][28][29][30][31] In the present study, we utilize the clickable hyperbranched polyester, prepared using dipropargyl, 4-(6hydroxyhexyloxy) isophthalate as the AB 2 type monomer, as a multifunctional crosslinker to afford amphiphilic hydrogels; hydrophilic PEG-diazides of different molecular weights were reacted with the hydrophobic clickable HB polyester to generate the crosslinked polymers. Sanyal and coworkers have used a similar click strategy using propargylated dendrimers and PEG-diazides to prepare hydrogels, which have been explored for drug delivery, sensing and as scaffolds for tissue engineering.…”