Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia

K, Amrath Raj B; Singh, Kumar Amerendra; Shah, Hitesh

doi:10.1016/j.jor.2020.05.022

Cited by 7 publications

(1 citation statement)

References 36 publications

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“…Bu nedenle kemik ağrısı olan hastaların daha dikkatli bir şekilde değerlendirilmesi gerektiğini düşünmekteyiz. Çalışmamızda literatürle benzer şekilde en sık etkilenen eklemler sırasıyla diz, kalça ve ayak bileğiydi (14,16,17). Malign hastalıklarda kalça en sık etkilenen ikinci eklem olarak karşımıza çıkarken, ayak bileği benign hastalıklarda en sık etkilenen ikinci eklemdi.…”

Section: Discussionunclassified

Kas iskelet sistemi yakınmalarında neoplastik hastalıkların değerlendirilmesi

Sözeri

2023

Jour Umraniye Pediatr

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Section: Discussionunclassified

Kas iskelet sistemi yakınmalarında neoplastik hastalıkların değerlendirilmesi

Sözeri

2023

Jour Umraniye Pediatr

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Back Pain

Walter

2023

Nelson Pediatric Symptom-Based Diagnosis: Common Diseases and Their Mimics

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Musculoskeletal involvement in childhood leukemia: Characteristics and survival outcomes

et al. 2022

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Background Childhood leukemia with musculoskeletal (MSK) involvement mimics various conditions, which consequently leads to diagnostic delays. The clinical implication of MSK involvement in this disease on survival outcomes is inconclusive. This study aimed to compare characteristics and survival outcomes between MSK and non-MSK involvement in childhood leukemia. Methods The medical records of children newly diagnosed with acute leukemia of an age under 15 years were retrospectively reviewed. Two-to-one nearest-neighbor propensity score-matching was performed to obtain matched groups with and without MSK involvement. The Kaplan–Meier method and log-rank test were then used to assess the effect of MSK involvement on survival outcomes. Results Of 1042 childhood leukemia cases, 81 (7.8%) children had MSK involvement at initial presentation. MSK involvement was more likely in children with acute lymphoblastic leukemia than acute myeloid leukemia (p < 0.05). Hematologic abnormalities were less frequent in the MSK involvement group (p < 0.05). The absence of peripheral blast cells was significantly higher in the MSK involvement group (17.3% vs 9.6%, p = 0.04). Normal complete blood counts with absence of peripheral blast cells were found 2.5% of the children with MSK involvement. By propensity score-matching for comparable risk groups of children with and without MSK involvement, the 5-year overall survival was not significantly different (48.2% vs 57.4%, respectively, p = 0.22), nor was event-free survival (43.3% vs 51.8%, respectively, p = 0.31). Conclusion Childhood leukemia with MSK involvement had the characteristics of minimal or absent hematologic abnormalities and peripheral blast counts.

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Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia

Cited by 7 publications

References 36 publications

Kas iskelet sistemi yakınmalarında neoplastik hastalıkların değerlendirilmesi

Kas iskelet sistemi yakınmalarında neoplastik hastalıkların değerlendirilmesi

Back Pain

Musculoskeletal involvement in childhood leukemia: Characteristics and survival outcomes

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