Orthopedic pathology of the lower extremities: Scintigraphic evaluation in the thigh, knee, and leg

Etchebehere, Elba; Etchebehere, Maurício; Gamba, Reinaldo; Belangero, William Dias; Camargo, Edwaldo E.

doi:10.1016/s0001-2998(98)80018-4

Cited by 37 publications

(15 citation statements)

References 85 publications

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“…Bone scintigraphy of the peripheral extremities is an excellent tool to detect orthopedic disorders [1][2][3][4][5][6][7][8][9][10][11][12][13][14][29][30][31]. However, the evidence on the value of hybrid imaging of the peripheral extremities is scarce.…”

Section: Discussionmentioning

confidence: 99%

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Wuest

Kuwert

Grunewald³

et al. 2007

Open Medicine

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AbstractBone scintigraphy, although quite sensitive to detect skeletal lesions, has a comparatively low specificity. Hybrid-cameras combining single-photon emission computed tomography (SPECT) and spiral-CT offer the opportunity to correlate scintigraphic information with high-quality visualization of morphology in one session. This may lead to an improvement in diagnostic accuracy and anatomic lesion localization. We present 11 patients, who underwent SPECT/CT of the feet (n=10) and hands (n = 1). The examinations were performed due to pain in foot or hand with the following suspected clinical diagnoses: arthrosis (n=1); fracture (n=3); osteomyelitis (n=4); reflex dystrophia (n=1); and, pain of unclear origin (n=2). All patients underwent SPECT/CT hybrid imaging using a dual-headed SPECT camera integrated with a 2-slice spiral CT scanner in one gantry. SPECT, CT, and SPECT/CT were evaluated independently from each other with respect to main diagnosis, anatomic lesion localization, and detection of a possible additional diagnosis. SPECT/CT improved lesion localization in 8 of 11 patients (73%) in comparison to SPECT alone, and in 4 of 11 patients (36%) in comparison to CT alone. Diagnostic accuracy was improved in 4 of 11 patients (36%) in comparison to either SPECT or CT alone. In conclusion, skeletal SPECT/CT improves diagnostic accuracy and lesion localization of orthopedic disorders in the feet and hands. The obtained results encouraged extensive studies to further investigate the potential gain in diagnostic accuracy brought about by SPECT/spiral-CT hybrid imaging in orthopedic disorders of the peripheral extremities.

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Section: Discussionmentioning

confidence: 99%

Skeletal SPECT/CT of the peripheral extremities -interdisciplinary approach in orthopaedic disorders-first clinical results

Wuest

Kuwert

Grunewald³

et al. 2007

Open Medicine

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“…Etchebehere et al noted that bone scans precede radiographic changes in osteonecrosis of the knee (Etchebehere et al 1998 ). Another established indication of SPECT/ CT is the assessment of osteochondritis dissecans (OCD) (Konala et al 2010 ).…”

Section: Cartilage and Osteochondral Lesionsmentioning

confidence: 99%

“…Etchebehere et al highlighted that in case of delayed healing of fractures, bone scans are able to differentiate between avascular and hypervascular non-unions and delayed unions (Etchebehere et al 1998 ). They further noted that SPECT accurately detects decreased metabolism associated with posttraumatic closure of the physeal plate, which could then lead to growth arrest and leg deformities.…”

Section: Shin Splint Syndrome Fractures Pseudoarthrosis and Osteonementioning

confidence: 99%

Nuclear Medicine Imaging of Knee Injuries

Hirschmann

Forrer

Testa

et al. 2015

Nuclear Medicine and Radiologic Imaging in Sports Injuries

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“…Various radiopharmaceuticals have been described in the literature under development in animals to allow imaging of cartilage as well as bone (Yu, Bartlett et al 1988;Yu, Shaw et al 1999). Other radiopharmaceuticals that target inflammation, osteophytes, cysts and sclerosis have also been described in a limited setting in the literature (Merrick 1992;Etchebehere, Etchebehere et al 1998). In positron emission spectroscopy (PET), 18-fluorodeoxyglucose (18-FDG) acts as a glucose analogue, taken up in cells within the body which have high glucose requirements.…”

Section: Bone Scansmentioning

confidence: 99%