Orthostasis Is Impaired Due to Fatiguing Intensive Acute Concentric Exercise Succeeded by Isometric Weight-Loaded Wall-Sit in Delayed-Onset Muscle Soreness: A Pilot Study

Abstract

The aim of the study was to investigate any indication of diminished orthostatic tolerance as a result of fatiguing intensive acute concentric exercise with a successive isometric wall-sit followed by an orthostatic stress test, with a special focus on any distinguishable alterations due to a delayed-onset muscle soreness effect. The exercise protocol was carried out among nineteen (10 female, 9 male) junior swimmers from the Hungarian National Swim Team. All athletes showed a positive orthostatic stress test right after our exercise protocol. The diastolic blood pressure was significantly lower due to the delayed-onset muscle soreness effect in the standing position after the supine position of the orthostatic stress test, in contrast to the athletes who did not experience delayed-onset muscle soreness. Furthermore, the heart rate was dysregulated in athletes with a delayed-onset muscle soreness effect when they assumed a supine position after the sustained standing position during the orthostatic stress test, in contrast to the athletes without delayed-onset muscle soreness. Interesting to note is that, in three subjects, the sustained standing position decreased the heart rate below the level of the initial supine position and six athletes experienced dizziness in the standing position, and all of these athletes were from the group that experienced delayed-onset muscle soreness. Accordingly, this study, for the first time, demonstrated that delayed-onset muscle soreness impairs orthostasis after unaccustomed fatiguing intensive acute concentric exercise with a successive isometric weight-loaded wall-sit; however, validation of this association should be investigated in a larger sample size.

Does Proprioception Involve Synchronization with Theta Rhythms by a Novel Piezo2 Initiated Ultrafast VGLUT2 Signaling?

“…Correspondingly, abnormal diastolic blood pressure and heart rate is a consequence of tilting in diabetes mellitus, indicating an impaired autonomous nervous system [87]. A recent observation confirms these perturbations in DOMS as well, which was demonstrated by an acute intensive exercise protocol combined with an isometric wall-sit and followed by an orthostasis test [88]. Indeed, atypical hippocampal-like metabotropic PLD-mGluR is homomeric to metabotropic GluK2 [32], and GluK2 is involved in the maintenance of glucose homeostasis [89].…”

Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism

“…In the meantime, syndecan-3 transduces external cell surface signals intracellularly through the actin cytoskeleton in order to participate in cell shape organization and this process is sugar-dependent [ 81 ]. Moreover, a recent pilot study found that DOMS-inducing fatiguing exercise, suggested to involve Piezo2 channelopathy as the primary injury phase [ 18 , 26 ], resulted in reduced orthostatic tolerance with associated abnormal changes in diastolic blood pressure and heart rate in a similar fashion to in diabetes mellitus [ 82 ].…”