Orthostatic cardiovascular profile of subjective well-being

Davydov, Dmitry M.; Czabak-Garbacz, R

doi:10.1016/j.biopsycho.2016.11.014

Cited by 8 publications

(4 citation statements)

References 70 publications

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“…Pain‐related effect on the baroreflex symmetry mechanism, which diminishes tachycardiac baroreflex in response to BP decrease (a putative “pain resilience” mechanism) may determine, as a byproduct, the symptoms of OI and POTS in some patients as one of multiple distinct pathophysiological subtypes within them . Its resilience attribute is concordant with findings of increased orthostatic heart rate response as a biomarker of more universal mechanism of protection against negative affect, chronic pain, and hemorrhage severity . Chronic pain is also frequently co‐morbid with arterial hypertension .…”

Section: Discussionmentioning

confidence: 89%

“…87 Its resilience attribute is concordant with findings of increased orthostatic heart rate response as a biomarker of more universal mechanism of protection against negative affect, chronic pain, and hemorrhage severity. 18,62,88 Chronic pain is also frequently co-morbid with arterial hypertension. 89 Pain-related effect on the baroreflex symmetry mechanism, which increases start point for bradycardiac baroreflex in response to BP increase (a putative "pain adaptation" mechanism) may determine, as a byproduct, a chronically elevated BP level in some patients.…”

Section: Discussionmentioning

confidence: 99%

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Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Davydov

Naliboff

Shahabi

et al. 2017

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Davydov

Naliboff

Shahabi

et al. 2017

Neurogastroenterology Motil

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show abstract

“…This represented an ineffective undercompensated cardiac preload response to the rehydration event, favoring cardiac afterload and accumulating the effect of the 'vasoconstrictor' form of BP rise. Such a predominantly 'vascular' mechanism regulating BP up-response to body water redistribution events, such as the lying position, may lead to habitually dysregulated cerebral and/or peripheral hypo-perfusions overcompensated by active cerebral and/or peripheral vasoconstriction 23 , 67 – 70 . This may contribute to the risk and higher severity of sensitization to pain in its dynamic domain 11 , 24 , 71 .…”

Section: Discussionmentioning

confidence: 99%

“…The reaction of BP in response to an acute dehydration event, such as active standing, might be mediated by atrial volume, high-pressure coronary, aortic, and carotid, as well as low-pressure pulmonary arterial mechanosensitive receptors that sense changes in central blood volume and arterial pressure 28 , 47 . However, incorrect interaction of these blood volume- and blood pressure-related mechanisms in response to regular dehydration events might impact multiple neurophysiologic, endocrine, and metabolic regulations in the central and peripheral activities of the brain, organs of the digestive system, muscles, and skin 23 , 25 , 45 , 47 , 49 . This, in turn, determines heterogeneous risks of chronic pain development with central and/or peripheral pain sensitization mechanisms, further impacting their severity 1 .…”

Section: Discussionmentioning

confidence: 99%

Impact of homeostatic body hydration status, evaluated by hemodynamic measures, on different pain sensitization paths to a chronic pain syndrome

Davydov,

de la Coba,

Contreras-Merino

et al. 2024

Sci Rep

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Contrasting findings on the mechanisms of chronic pain and hypertension development render the current conventional evidence of a negative relationship between blood pressure (BP) and pain severity insufficient for developing personalized treatments. In this interdisciplinary study, patients with fibromyalgia (FM) exhibiting clinically normal or elevated BP, alongside healthy participants were assessed. Different pain sensitization responses were evaluated using a dynamic 'slowly repeated evoked pain' (SREP) measure, as well as static pain pressure threshold and tolerance measures. Cardiovascular responses to clino-orthostatic (lying-standing) challenges were also examined as acute re- and de-hydration events, challenging cardiovascular and cerebrovascular homeostasis. These challenges involve compensating effects from various cardiac preload or afterload mechanisms associated with different homeostatic body hydration statuses. Additionally, hair cortisol concentration was considered as a factor with an impact on chronic hydration statuses. Pain windup (SREP) and lower pain threshold in FM patients were found to be related to BP rise during clinostatic (lying) rehydration or orthostatic (standing) dehydration events, respectively. These events were determined by acute systemic vasoconstriction (i.e., cardiac afterload response) overcompensating for clinostatic or orthostatic cardiac preload under-responses (low cardiac output or stroke volume). Lower pain tolerance was associated with tonic blood pressure reduction, determined by permanent hypovolemia (low stroke volume) decompensated by permanent systemic vasodilation. In conclusion, the body hydration status profiles assessed by (re)activity of systemic vascular resistance and effective blood volume-related measures can help predict the risk and intensity of different pain sensitization components in chronic pain syndrome, facilitating a more personalized management approach.

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Development of an Experimental and Digital Cardiovascular Arterial Model for Transient Hemodynamic and Postural Change Studies: “A Preliminary Framework Analysis”

Hewlin

Kizito

2017

Cardiovasc Eng Tech

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The ultimate goal of the present work is to aid in the development of tools to assist in the treatment of cardiovascular disease. Gaining an understanding of hemodynamic parameters for medical implants allow clinicians to have some patient-specific proposals for intervention planning. In the present work an experimental and digital computational fluid dynamics (CFD) arterial model consisting of a number of major arteries (aorta, carotid bifurcation, cranial, femoral, jejunal, and subclavian arteries) were fabricated to study: (1) the effects of local hemodynamics (flow parameters) on global hemodynamics (2) the effects of transition from bedrest to upright position (postural change) on hemodynamics, and (3) diffusion of dye (medical drug diffusion simulation) in the arterial system via experimental and numerical techniques. The experimental and digital arterial models used in the present study are the first 3-D systems reported in literature to incorporate the major arterial vessels that deliver blood from the heart to the cranial and femoral arteries. These models are also the first reported in literature to be used for flow parameter assessment via medical drug delivery and orthostatic postural change studies. The present work addresses the design of the experimental and digital arterial model in addition to the design of measuring tools used to measure hemodynamic parameters. The experimental and digital arterial model analyzed in the present study was developed from patient specific computed tomography angiography (CTA) scans and simplified geometric data. Segments such as the aorta (ascending and descending) and carotid bifurcation arteries of the experimental and digital arterial model was created from online available patient-specific CTA scan data provided by Charite' Clinical and Research Hospital. The cranial and coronary arteries were simplified arterial geometries developed from dimensional specification data used in previous work. For the patient specific geometries, a MATLAB code was written to upload the CTA scans of each artery, calculate the centroids, and produce surface splines at each discrete cross section along the lumen centerline to create the patient specific arterial geometries. The MATLAB code worked in conjunction with computer aided software (CAD) Solidworks to produce solid models of the patient specific geometries and united them with the simplified geometries to produce the full arterial model (CAD model). The CAD model was also used as a blueprint to fabricate the experimental model which was used for flow visualization via particle imaging velocimetry (PIV) and postural change studies. A custom pulse duplicator (pulsatile pump) was also designed and developed for the present work. The pulse duplicator is capable of producing patient-specific volumetric waveforms for inlet flow to the experimental arterial model. A simple fluid structure interaction (FSI) study was also conducted via optical techniques to establish the magnitude of vessel diameter change due to the pulsatile flow....

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Orthostatic cardiovascular profile of subjective well-being

Cited by 8 publications

References 70 publications

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Impact of homeostatic body hydration status, evaluated by hemodynamic measures, on different pain sensitization paths to a chronic pain syndrome

Development of an Experimental and Digital Cardiovascular Arterial Model for Transient Hemodynamic and Postural Change Studies: “A Preliminary Framework Analysis”

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