Orthostatic hypotension in the anesthetized rabbit in the sitting position exceeds cerebral autoregulation

Willeford, Breanna

doi:10.1515/jbcpp.2011.025

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2022

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“…During HoB tilting, a significant decrease in mean carotid ABP and heart rate was recorded in our sheep. Orthostatic hypotension was described previously in anesthetized rabbits as a dysfunction of the baroreflex system during anesthesia (Willeford, 2011). Acute gravitational stress is thereby thought to pool venous blood in the lower half of the body, thus transiently reducing venous backflow to the heart and consequently reducing cardiac output.…”

Section: Discussionmentioning

confidence: 99%

Venous dynamics in anesthetized sheep govern postural‐induced changes in cerebrospinal fluid pressure comparable to those in humans

Trimmel

Podgoršak

Oertel

et al. 2022

Physiological Reports

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Intracranial pressure (ICP), i.e., the pressure inside the skull, comprises arterial, venous, and cerebrospinal fluid (CSF) pressures (Kasprowicz et al., 2016). Davson's equation describes ICP and its dependency on CSF outflow resistance (R out ), CSF production, and sagittal sinus pressure (SSP) (Davson et al., 1970). Aside from intracranial factors, extracranial factors are known to play a role in the maintenance of ICP (O'Connell, 1943). In particular,

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Section: Discussionmentioning

confidence: 99%