Orthostatic intolerance in the chronic fatigue syndrome

Schondorf, Ronald; Benoit, Julie; Wein, Theodore; Phaneuf, Denis

doi:10.1016/s0165-1838(98)00177-5

Cited by 130 publications

(87 citation statements)

References 56 publications

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“…Orthostatic intolerance was defined as instability in maintaining normal consciousness without significant symptoms such as disabling fatigue, dizziness, diminished concentration, tremulousness, sweating, lightheadedness, visual disturbance, palpitations, and nausea while standing, or any perturbation that mimics the hemodynamic consequences of standing. 8 In addition, we studied 11 patients with OI but without CFS (group OI) and 27 healthy control subjects (controls; Table 1). Postural orthostatic tachycardia syndrome (POTS) was diagnosed in 7 (27%) of the CFSOI(+) patients and in 3 (27%) of the OI patients with an increase of heart rate >30 beats/minute during a 10-minute standing test.…”

Section: Study Populationmentioning

confidence: 99%

Small Heart With Low Cardiac Output for Orthostatic Intolerance in Patients With Chronic Fatigue Syndrome

Miwa

Fujita

2011

Clinical Cardiology

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Background: The etiology of chronic fatigue syndrome (CFS) is unknown. Orthostatic intolerance (OI) is common in CFS patients. Recently, small heart with low cardiac output has been postulated to be related to the genesis of both CFS and OI. Hypothesis: Small heart is associated with OI in patients with CFS. Methods: Study CFS patients were divided into groups of 26 (57%) CFSOI(+) and 20 (43%) CFSOI(−) according to the presence or absence of OI. In addition, 11 OI patients and 27 age-and sex-matched control subjects were studied. Left ventricular (LV) dimensions and function were determined echocardiographically. Results:The mean values of cardiothoracic ratio, systemic systolic and diastolic pressures, LV end-diastolic dimension, LV end-systolic dimension, stroke volume index, cardiac index, and LV mass index were all significantly smaller in CFSOI(+) patients than in CFSOI(−) patients and healthy controls, and also in OI patients than in controls. A smaller LV end-diastolic dimension (<40 mm) was significantly (P < 0.05) more prevalently noted in CFSOI(+) (54%) and OI (45%) than in CFSOI(−) (5%) and controls (4%). A lower cardiac index (<2 L/min/mm 2 ) was more prevalent in CFSOI(+) (65%) than in CFSOI(−) (5%, P < 0.01), OI (27%), and controls (11%, P < 0.01). Conclusions: A small size of LV with low cardiac output was noted in OI, and its degree was more pronounced in CFSOI(+). A small heart appears to be related to the genesis of OI and CFS via both cerebral and systemic hypoperfusion. CFSOI(+) seems to constitute a well-defined and predominant subgroup of CFS.

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Section: Study Populationmentioning

confidence: 99%

Small Heart With Low Cardiac Output for Orthostatic Intolerance in Patients With Chronic Fatigue Syndrome

Miwa

Fujita

2011

Clinical Cardiology

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“…CFS has sometimes been referred to as the "chronic fatigue immune dysfunction syndrome", because a number of studies have found irregularities of the immune system. Recently, the role of abnormal autonomic function in the pathogenesis of chronic fa-tigue syndrome has been investigated, suggesting potential significance in the diagnostic pro-cess of this condition in the future [24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Chronic fatigue syndrome in 57-year-old woman

et al. 2014

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AbstractChronic fatigue syndrome (CFS) is characterized by unexplained fatigue lasting for more than 6 months and accompanied by flulike symptoms. It most commonly affects women aged between 30 and 60 years. To date, clear diagnostic criteria allowing for unambiguous diagno-sis of CFS have not been established. We present a case of a 57-year-old woman with chronic fatigue syndrome in order to showcase the symptoms of this condition and propose a diagnos-tic protocol.

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“…17,42,43 Both CFS and orthostatic intolerance affects many young people, predominantly women. Many symptoms of OI appear to be related to reduced cerebral blood flow.…”

Section: Similarities and Overlaps Between Cfs And Oimentioning

confidence: 99%

“…[36][37][38][39][40][41]44,47 Also studies in adolescents suggest that POTS physiology underlies OI in the majority of CFS patients. [41][42][43][44] POTS is a frequent finding in patients with CFS. [41][42][43][44] Clinical evaluation of CFS patients should include response to standing.…”

Section: Pathopysiology Of Oimentioning

confidence: 99%

Small Heart as a Constitutive Factor Predisposing to Chronic Fatigue Syndrome

Miwa¹

2012

An International Perspective on the Future of Research in Chronic Fatigue Syndrome

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Orthostatic intolerance in the chronic fatigue syndrome

Cited by 130 publications

References 56 publications

Small Heart With Low Cardiac Output for Orthostatic Intolerance in Patients With Chronic Fatigue Syndrome

Small Heart With Low Cardiac Output for Orthostatic Intolerance in Patients With Chronic Fatigue Syndrome

Chronic fatigue syndrome in 57-year-old woman

Small Heart as a Constitutive Factor Predisposing to Chronic Fatigue Syndrome

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