Orthostatic Tremor: A Spectrum of Fast and Slow Frequencies or Distinct Entities?

Rigby, Heather; Rigby, Matthew H.; Caviness, John N.

doi:10.7916/d8s75fhk

Cited by 18 publications

(2 citation statements)

References 24 publications

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“…The only tremor other than functional tremor in which there is left-right coherence is orthostatic tremor (OT), but this type of tremor has a higher frequency (12)(13)(14)(15)(16)(17)(18). 11 The patient's tremor may share some similarities with a slow OT that has been previously described, which can have a frequency in the same range (10)(11) and have right-left coherence (although the level of coherence is lower than in classic OT 12 ). However, both classic and slow OT are tremors that characteristically appear only during standing, which is not the case here.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype

Vial

McGurrin

Osterholt

et al. 2023

Movement Disord Clin Pract

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Background The concept of a myopathy with associated tremor (“myogenic tremor”) in humans has been previously described for specific MYBPC1 (Myosin‐Binding Protein C) variants. Here we report for the first time an individual with tremor who was found to have a de‐novo likely pathogenic variant in Myosin Heavy Chain 7 (MYH7). We provide a detailed electrophysiological characterization of the tremor syndrome in a human individual with a myopathy and this pathogenic MYH7 variant to provide further insight in the phenotypic spectrum and pathomechanism of myogenic tremors in skeletal sarcomeric myopathies. Methods Electromyographic recordings were obtained from facial muscles, as well as bilateral upper and lower extremities. Results 10 to 11 Hz activity was observed in the face and extremities during recordings with muscle activation. There were intermittent episodes of significant left–right coherence that would modulate across muscle groups throughout the recording, but no coherence between muscles at different levels of the neuraxis. Conclusions A possible explanation for this phenomenon is that the tremor originates at the sarcomere level within muscles, which is then picked up by muscle spindles and leads to activating input to the neuraxis segment. At the same time, the stability of the tremor frequency does suggest the presence of central oscillators at the segmental level. Thus, further studies will be needed to determine the origin of myogenic tremor and to better understand the pathomechanism.

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Section: Discussionmentioning

confidence: 99%

Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype

Vial

McGurrin

Osterholt

et al. 2023

Movement Disord Clin Pract

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“…While OT is often isolated, in one series of 41 patients, 4 patients also had PD [150]. Orthostatic tremor (particularly if under 13 Hz) may be associated with other neurologic disorders [151], including ET [150,[152][153][154] and PD [149]. Leg tremor in patients with ET or PD should be differentiated from OT [50].…”

Section: Orthostatic Tremormentioning

confidence: 98%

Parkinsonism and tremor syndromes

Bellows

Jankovic

2022

Journal of the Neurological Sciences

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Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society

et al. 2017

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Background Consensus criteria for classifying tremor disorders were published by the International Parkinson and Movement Disorder Society in 1998. Subsequent advances with regard to essential tremor, tremor associated with dystonia, and other monosymptomatic and indeterminate tremors make a significant revision necessary. Objectives Convene an international panel of experienced investigators to review the definition and classification of tremor. Methods Computerized MEDLINE searches in January 2013 and 2015 were conducted using a combination of text words and MeSH terms: “tremor”, “tremor disorders”, “essential tremor”, “dystonic tremor”, and “classification” limited to human studies. Agreement was obtained using consensus development methodology during four in‐person meetings, two teleconferences, and numerous manuscript reviews. Results Tremor is defined as an involuntary, rhythmic, oscillatory movement of a body part and is classified along two axes: Axis 1—clinical characteristics, including historical features (age at onset, family history, and temporal evolution), tremor characteristics (body distribution, activation condition), associated signs (systemic, neurological), and laboratory tests (electrophysiology, imaging); and Axis 2—etiology (acquired, genetic, or idiopathic). Tremor syndromes, consisting of either isolated tremor or tremor combined with other clinical features, are defined within Axis 1. This classification scheme retains the currently accepted tremor syndromes, including essential tremor, and provides a framework for defining new syndromes. Conclusions This approach should be particularly useful in elucidating isolated tremor syndromes and syndromes consisting of tremor and other signs of uncertain significance. Consistently defined Axis 1 syndromes are needed to facilitate the elucidation of specific etiologies in Axis 2. © 2017 International Parkinson and Movement Disorder Society

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Orthostatic Tremor: A Spectrum of Fast and Slow Frequencies or Distinct Entities?

Cited by 18 publications

References 24 publications

Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype

Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype

Parkinsonism and tremor syndromes

Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society

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