Orthotopic liver transplantation in patients over 60 years of age

Donor Age-Based Analysis of Liver Transplantation Outcomes: Short- and Long-Term Outcomes Are Similar Regardless of Donor Age

“…4,6,20 In this report, we investigated our single-center results using older donors and compared these based on both recipient and donor age, comparing age 60 years or older with age younger than 60, using 60 years because it has historically been used as an age cut-off. 6,14,18,21 In 857 liver transplant cases stratified based on these age specifications, we were unable to demonstrate any adverse impact based on donor age 60 or above. This included no increased risk of primary graft nonfunction (PNF), no increased rate of hepatic artery thrombosis (HAT), and no increased incidence of long-term graft dysfunction (including recurrent infection with HCV).…”

“…The incidence of severe viral C recurrence, diagnosed by liver biopsy, was also similar across donor age groups. 21 The recent introduction of highly effective hepatitis C antiviral agents will likely reduce this concern because many transplant recipients will have been treated before liver transplantation, or will be able to undergo antiviral treatment in the post-transplantation setting. We previously reported our initial experience with use of older donors for liver transplantation, 18 and that initial report demonstrated equivalent results in short-and mediumterm follow-up.…”

Liver transplantation in recipients over 65 yr old: a single center experience

“…The discrepancy between available donor organs and patients awaiting transplantation has led to evaluation of selection and listing criteria for LT, including transplantation of elderly patients (older than 65 yr), with the goal of maximizing survival outcomes (15–19). Numerous studies have confirmed that transplant surgery can be performed safely in elderly patients (12, 20–29) (Table 4). Kemmer (29) in a recent review describe the transplantation trends in the older recipient using the United Network for Organ Sharing (UNOS) database.…”

A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients

“…We classified the recipients into 2 groups: an elderly group (E group; ≥60 years of age) and a younger group (Y group; <60 years of age), with age 60 years established as the cutoff due to its usage in similar studies. 8-10 Recipient variables, including the characteristics, patient survival, and cause of death, were collected and used for the analysis. To assess the impact of recipient factors on the survival, a Cox proportional analysis was performed in all recipients as well as in the Y and E groups.…”