Orthotopic partial hepatic transplantation in dog

Mizumoto, Ryuji; Yokota, Takashi; Osawa, Jiro; Kono, Akinori; Otoshi, Eriko

doi:10.1007/bf02469041

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…APOLT, in which a reduced-size graft orthotopically replaces the resected lobe in the recipient, has the definite advantages over HALT that both the reduced native liver and the reduced graft can obtain optimal accommodation and that a position close to the right atrium may improve hepatic venous outflow of the graft [4,14,22]. Nevertheless, there still have been reports of insufficient portal blood flow in a case of noncirrhotic metabolic liver disease [5,9,23], in which the portal vein to the native liver was finally banded [5,23].…”

Section: Introductionmentioning

confidence: 99%

Portal Blood Flow and Liver Regeneration in Auxiliary Partial Orthotopic Liver Transplantation in a Canine Model

et al. 1999

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Functional competition has been shown to lead to a detrimental outcome in auxiliary liver transplantation. We evaluated the interaction in auxiliary partial orthotopic liver transplantation between the native liver and the graft in terms of portal flow and regeneration. The need for diversion of the portal flow to the graft was also assessed. Reduced-size liver grafts were transplanted orthotopically after partial hepatectomy in beagles. There were two groups: the preserved group, where portal inflow to the native liver was preserved, and the ligated group, where it was interrupted. Portal flow was measured serially and liver regeneration was evaluated on postoperative day 5. Functional competition was not observed in the preserved group. On the other hand, ligation of the native liver portal vein had no obviously detrimental effects on the remnant native liver. This leads to the conclusion that the portal vein to the native liver can be safely ligated to prevent functional competition.

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Section: Introductionmentioning

confidence: 99%

Portal Blood Flow and Liver Regeneration in Auxiliary Partial Orthotopic Liver Transplantation in a Canine Model

et al. 1999

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Transplantation of hepatic segments

Broelsch¹,

Emond

1988

Progress in Surgery of the Liver, Pancreas and Biliary System

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Orthotopic transplantation of a partial hepatic autograft in dogs

et al. 1997

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The purpose of this study was to investigate the availability of an orthotopic transplantation of partial hepatic autograft in dogs as a means of surgical training. Male mongrel dogs weighting 10-15 kg were used. The left lobe of the liver was harvested while preserving the left branches of the portal vein, hepatic artery and bile duct, and the left hepatic vein. The remnant liver was removed while preserving the inferior vena cava using a veno-venous bypass. Orthotopic transplantation of the autograft was performed while anastomosing the left hepatic vein to the inferior vena cava, portal and arterial reconstruction, and external biliary drainage. Thirteen out of 29 dogs survived more than 48 h after transplantation. However, 6 out of 13 dogs were sacrificed after developing bile peritonitis due to a dislodgement of the biliary catheter, and only two dogs were able to survive for 7 days after transplantation. The arterial ketone body ratio recovered to 1.0 within 1 h after reperfusion, and the ratio of the dogs that survived for more than 48 h remained above 1.0 until sacrifice. Orthotopic transplantation of a partial hepatic autograft is a useful and simple procedure to train surgeons for partial liver transplantation.

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Orthotopic partial hepatic transplantation in dog

Cited by 7 publications

References 8 publications

Portal Blood Flow and Liver Regeneration in Auxiliary Partial Orthotopic Liver Transplantation in a Canine Model

Portal Blood Flow and Liver Regeneration in Auxiliary Partial Orthotopic Liver Transplantation in a Canine Model

Transplantation of hepatic segments

Orthotopic transplantation of a partial hepatic autograft in dogs

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