Orthotopic VX rabbit tongue cancer model with FDG–PET and histologic characterization

Stack, Brendan C.; Ye, John; Bartel, Twyla; Shafirstein, Gal; Chen, Chien; Siegel, Eric R.; Singh, Bipin; Thacker, Samta; Lowe, Val J.; Nagarkar, Vivek V.

doi:10.1002/hed.23105

Cited by 4 publications

(1 citation statement)

References 74 publications

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“…The magnitude of tumour invasion is often far greater than is visibly apparent and may be accompanied by small lymph node metastasis early during disease progression. Furthermore, some smaller malignant lesions or metastases cannot be detected by conventional imaging; thus, a more effective and convenient examination method must be devised in order to improve the sensitivity of preoperative detection of metastasis, detect cervical lymph node metastases and improve metastasis staging. In our study, 18 TSCC cases were assessed by preoperative PET/CT examination, which had a higher sensitivity and specificity for evaluating the cervical lymph node metastasis compared with MRI examination alone, as confirmed on postoperative histopathological analysis.…”

Section: Discussionmentioning

confidence: 99%

Application value of MRI combined with positron emission tomography (PET)/CT in diagnosis and preoperative staging of tongue squamous cell carcinoma

Chen

Zhang

et al. 2015

J Med Imag Rad Onc

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Section: Discussionmentioning

confidence: 99%

Application value of MRI combined with positron emission tomography (PET)/CT in diagnosis and preoperative staging of tongue squamous cell carcinoma

Chen

Zhang

et al. 2015

J Med Imag Rad Onc

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A hand-held beta imaging probe for FDG

et al. 2012

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Objectives Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. Methods We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDG-avid primary tumors and metastases in an animal model. Results We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model. Conclusions It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

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Lingual Sarcoma and its Treatment with Partial Glossectomy in a Pet Rabbit (Oryctolagus Cuniculus)

Bulliot

Flenghi

Levrier

2019

Journal of Exotic Pet Medicine

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Orthotopic VX rabbit tongue cancer model with FDG–PET and histologic characterization

Abstract: This model may be a useful model of orthotopic head and neck cancer for future surgical or imaging research.

Cited by 4 publications

References 74 publications

Application value of MRI combined with positron emission tomography (PET)/CT in diagnosis and preoperative staging of tongue squamous cell carcinoma

Application value of MRI combined with positron emission tomography (PET)/CT in diagnosis and preoperative staging of tongue squamous cell carcinoma

A hand-held beta imaging probe for FDG

Lingual Sarcoma and its Treatment with Partial Glossectomy in a Pet Rabbit (Oryctolagus Cuniculus)

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