OS060. Exercise training promotes placental growth and development in an animal model of preeclampsia superimposed on chronic hypertension

Genest, Dominique S.; Falcao, Stéphanie; Michel, Catherine; Lacasse, Andrée-Anne; Vaillancourt, Claude; Gutkowska, Jolanta; Lavoie, Julie L.

doi:10.1016/j.preghy.2012.04.061

Cited by 4 publications

(7 citation statements)

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“…Exercise increased placental villous area and vascular volume, with improved placental perfusion and transport capacity. Exercise training also prevented a rise in blood pressures normally observed at the end of pregnancy in sedentary mice [24]. There was normalization of angiotensin II type 1 receptor in trained mice suggesting modulation of renin angiotensin system by exercise [41].…”

Section: Insulin Resistancementioning

confidence: 83%

“…Furthermore, there was significant improvement of proteinuria and cardiac hypertrophy in mice subjected to exercise [40]. The authors concluded that exercise training both before and during pregnancy was associated with a reduction in features of pre-eclampsia with or without chronic hypertension in mice [17,24,41].…”

Section: Insulin Resistancementioning

confidence: 97%

“…There is evidence that exercise training improves the angiogenic balance in normal pregnant women [22,23] and modifies it favorably in laboratory-based studies of mice with hypertensive disorders of pregnancy [17,24,25].…”

Section: Angiogenic Balance and Placental Developmentmentioning

confidence: 99%

“…Sedentary mice with pre-eclampsia with substantial placental pathology were subjected to exercise training before and during pregnancy, and exercise normalized the pathology by promoting placental angiogenesis and development [24]. There was normalization of VEGF expression, a decrease in circulating and placental soluble sFlt-1 and other placental markers, improved vascular reactivity, and reduction in placental disease.…”

Section: Insulin Resistancementioning

confidence: 99%

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Advice on exercise for pregnant women with hypertensive disorders of pregnancy

Chawla

Anim-Nyame

2014

Intl J Gynecology & Obste

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Reports on advice about exercise for women with hypertensive disorders of pregnancy are reviewed and how exercise could influence long-term cardiovascular risk is assessed. Exercise in pregnancy seems to be beneficial in pregnancies complicated by hypertension. However, the intensity of the exercise to be recommended remains unclear. Further research is required to inform national and international guidelines for women who develop hypertension during pregnancy.

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Section: Insulin Resistancementioning

confidence: 83%

Section: Insulin Resistancementioning

confidence: 97%

Section: Angiogenic Balance and Placental Developmentmentioning

confidence: 99%

Section: Insulin Resistancementioning

confidence: 99%

See 2 more Smart Citations

Advice on exercise for pregnant women with hypertensive disorders of pregnancy

Chawla

Anim-Nyame

2014

Intl J Gynecology & Obste

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“…Maternal environment, lifestyle and other factors may alter some functions of the placenta, which may pose potential health risks to the growth and development trajectory of the fetus; in addition, it is an important factor leading to the metabolic diseases during pregnancy ( Furrer & Handschin, 2015 ; Genest et al, 2012 ). Pre-eclampsia (PE) is a human pregnancy-specific disease and is the primary cause of maternal mortality, affecting around 2–8% of the pregnancies, worldwide ( Gealekman et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of swimming before and during pregnancy on placental angiogenesis and perinatal outcome in high-fat diet-fed mice

Zhu

Chen

Wang

2023

PeerJ

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Background We explored the mechanism underlying exercise-mediated placental angiogenesis and perinatal outcome using mouse models. Methods Three-week-old C57BL/6 female mice were randomly divided into four experimental groups: standard-chow diet (SC), standard chow diet + exercise (SC-Ex), high-fat diet (HFD), and high-fat diet + exercise (HFD-Ex). After 13 weeks of exercise intervention, the male and female mice were caged. Approximately six to seven pregnant female mice from each experimental group were randomly selected for body composition, qRT-PCR, histological, and western blot analysis. The remaining mice were allowed to deliver naturally, and the perinatal outcome indexes were observed. Rusults The results showed that exercise intervention significantly improved the body composition and glucose tolerance in HFD-fed pregnant mice. The HFD group showed adipocyte infiltration, placental local hypoxia, and villous vascular thrombosis with a significant (p < 0.05) increase in the expression of VEGF and ANGPT1 proteins. Exercise intervention significantly elevated the expression of PPARγ, alleviated hypoxia and inflammation-related conditions, and inhibited angiogenesis. sFlt-1 mRNA in HFD group was significantly higher than that in SC group (p < 0.05). Furthermore, the HFD significantly reduced (p < 0.05) the fertility rate in mice. Conclusions Thus, HFD aggravates placental inflammation and the hypoxic environment and downregulates the expression of PPARγ and PPARα in the placenta. However, exercise intervention can significantly alleviate these conditions.

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