OSA and Prognosis After Acute Cardiogenic Pulmonary Edema

Uchôa, Carlos Henrique Gomes; Pedrosa, Rodrigo Pinto; Javaheri, Shahrokh; Geovanini, Glaucylara Reis; Carvalho, Martinha Millianny Barros de; Torquatro, Ana Claudia S.; Leite, Ana Paula Dornelas Leão; Gonzaga, Carolina C.; Bertolami, Adriana; Amodeo, Celso; Petisco, Ana Cláudia Gomes Pereira; Barbosa, José Eduardo Martins; Macedo, Thiago Andrade; Bortolotto, Luiz Aparecido; Oliveira, Múcio Tavares de; Lorenzi‐Filho, Geraldo; Drager, Luciano F.

doi:10.1016/j.chest.2017.08.003

Cited by 29 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to validate the portable sleep monitoring in this population, 100 consecutive patients at the Instituto do Coração performed simultaneous full polysomnography, as previously described ( 17 ). The sleep study is scored as previously described ( 18 ). Apnea is defined by a ≥90% decrease in the airflow from the baseline value for ≥10 seconds.…”

Section: Methodsmentioning

confidence: 99%

“…We further classified apnea in obstructive or central based on the presence or absence, respectively, of respiratory-related chest wall excursions. Hypopnea is defined by a ≥30% decrease in the airflow from the baseline value that lasted ≥10 seconds and occurred in conjunction with ≥3% oxygen desaturation ( 18 ). OSA is defined by an AHI ≥15 events / hour, because mild OSA seems to not have significant cardiovascular consequences ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic

Cruz

Drager

Queiróz

et al. 2021

Clinics

Self Cite

View full text Add to dashboard Cite

OBJECTIVES: To describe the MORPHEOS (Morbidity in patients with uncontrolled HTN and OSA) trial, and describe the challenges imposed by the COVID-19 pandemic. METHODS: MORPHEOS is a multicenter (n=6) randomized controlled trial designed to evaluate the blood pressure (BP) lowering effects of treatment with continuous positive airway pressure (CPAP) or placebo (nasal strips) for 6 months in adult patients with uncontrolled hypertension (HTN) and moderate-to-severe obstructive sleep apnea (OSA). Patients using at least one antihypertensive medication were included. Uncontrolled HTN was confirmed by at least one abnormal parameter in the 24-hour ABPM and ≥80% medication adherence evaluated by pill counting after the run-in period. OSA was defined by an apnea-hypopnea index ≥15 events/hours. The co-primary endpoints are brachial BP (office and ambulatory BP monitoring, ABPM) and central BP. Secondary outcomes include hypertension-mediated organ damage (HMOD) to heart, aorta, eye, and kidney. We pre-specified several sub-studies from this investigation. Visits occur once a week in the first month and once a month thereafter. The programmed sample size was 176 patients but the pandemic prevented this final target. A post-hoc power analysis will be calculated from the final sample. ClinicalTrials.gov: NCT02270658. RESULTS: The first 100 patients are predominantly males (n=69), age: 52±10 years, body mass index: 32.7±3.9 kg/m 2 with frequent co-morbidities. CONCLUSIONS: The MORPHEOS trial has a unique study design including a run-in period; pill counting, and detailed analysis of hypertension-mediated organ damage in patients with uncontrolled HTN that will allow clarification of the impact of OSA treatment with CPAP.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic

Cruz

Drager

Queiróz

et al. 2021

Clinics

Self Cite

View full text Add to dashboard Cite

show abstract

“…In order to validate the portable sleep monitoring in this population, 100 consecutive patients at the Instituto do Corac¸ão performed simultaneous full polysomnography, as previously described (17). The sleep study is scored as previously described (18). Apnea is defined by a X90% decrease in the airflow from the baseline value for X10 seconds.…”

Section: Portable Sleep Monitoringmentioning

confidence: 99%

Prevention of Parkinson's disease-related sudden death

Scorza¹,

Almeida²,

Scorza³

et al. 2021

Clinics

View full text Add to dashboard Cite

show abstract

“…Obstructive sleep apnea (OSA) affects more than 100 million adults all over the world [1]. Now, OSA has been recognized as one of the important causes or factors of worsening for various renal injury [2], cardiovascular diseases [3], cerebrovascular damage [4], asthma [5], and pulmonary edema [6]. Several theories have been developed to explain the excess risks among individuals with OSA, including oxidative stress, hypoxemia, inflammation, and hypertension [2].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload

et al. 2019

View full text Add to dashboard Cite

Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. Recent studies have indicated H2 can be used as a novel antioxidant to protect cells. The present study was designed to investigate the protective effects of H2 against chronic intermittent hypoxia (CIH)-induced renal injury and its correlation mechanism involved in iron metabolism. We found that CIH-induced renal iron overloaded along with increased apoptosis and oxidative stress. Iron accumulates mainly occurred in the proximal tubule epithelial cells of rats as showed by Perl’s stain. Moreover, we found that CIH could promote renal transferrin receptor and divalent metal transporter-1 expression, inhibit ceruloplasmin expression. Renal injury, apoptosis and oxidative stress induced by CIH were strikingly attenuated in H2 treated rats. In conclusion, hydrogen may attenuate CIH-induced renal injury at least partially via inhibiting renal iron overload.

show abstract

OSA and Prognosis After Acute Cardiogenic Pulmonary Edema

Cited by 29 publications

References 29 publications

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic

Prevention of Parkinson's disease-related sudden death

Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload

Contact Info

Product

Resources

About