Oscillation and bistable switching dynamical behavior of p53 regulated by PTEN upon DNA damage

Dual roles of SIRT1 in the BAX switch through the P53 module: A mathematical modeling study

“…More importantly, cell fate is regulated by P53 dynamics [24] . These facts have driven a number of theoretical studies to identify the potential dynamics of P53 controlled by its key regulator using the bifurcation method [25] , [26] , [27] , [28] , [29] , [30] . The mainstream point of view is that P53 oscillation requires a P53-MDM2 negative feedback loop (NFL) gene network structure.…”