The special issue entitled "Mathematical modelling, nonlinear dynamics, bifurcation, synchronization and control of mechanisms driven by power supply," published by The European Physical Journal: Special Topics (EPJST), aims to bring into discussion works involving nonlinear and dynamic and chaotic behaviors, which are frequently found in mechanical and electromechanical systems, nonlinear circuits, and biologically inspired systems, stimulating the integration of findings on the nonlinear dynamics that can be observed in various systems in the physical sciences and engineering. This special issue presents 27 papers concerning the dynamics and control of flexible structure systems, nonideal systems, energy harvesting problems, and vibration absorbers. In addition, the papers address problems involving chaos control of nonlinear oscillations, phase-locked loops, synchronization of nonlinear oscillators, dynamics of bio-inspired and biostructural systems, nonlinear methods, and nonlinear circuits.