Oscillations in collective cell migration

Petrolli, Vanni; Boudou, Thomas; Balland, Martial; Cappello, Giovanni

doi:10.1016/b978-0-12-820310-1.00004-5

Cited by 10 publications

(5 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4,12] Superimposed on these spatial patterns, temporal oscillations in cellular motion have also been reported on both circular and rectangular patterns. [13][14][15][16] Cellular monolayers on microstructured substrates also exhibit specific collective dynamics. We have recently investigated the collective migration of endothelial monolayers on microgrooved substrates that constrain the orientation and direction of migration of each cell along the axis of the grooves, a process known as "contact guidance", without imposing border effects on the monolayer.…”

Section: Constrained Collective Cell Migration In Vitro What Patterns...mentioning

confidence: 99%

See 1 more Smart Citation

Physiological ramifications of constrained collective cell migration

Leclech

Barakat

2023

BioEssays

View full text Add to dashboard Cite

Constraining collective cell migration in vitro using different types of engineered substrates such as microstructured surfaces or adhesive patterns of different shapes and sizes often leads to the emergence of specific patterns of motion. Recently, analogies between the behavior of cellular assemblies and that of active fluids have enabled significant advances in our understanding of collective cell migration; however, the physiological relevance and potential functional consequences of the resulting migration patterns remain elusive. Here we describe the different patterns of collective cell migration that have been reported in vitro in response to geometrical constraints, explore the in vivo pertinence of the in vitro systems used to impose the geometrical constraints, and discuss the potential physiological ramifications of the collective migration patterns that emerge as a result of physical constraints. We conclude by highlighting key upcoming challenges in the exciting field of constrained collective cell migration.

show abstract

Section: Constrained Collective Cell Migration In Vitro What Patterns...mentioning

confidence: 99%

“…[ 4,12 ] Superimposed on these spatial patterns, temporal oscillations in cellular motion have also been reported on both circular and rectangular patterns. [ 13–16 ]…”

Section: Constrained Collective Cell Migration In Vitromentioning

confidence: 99%

Physiological ramifications of constrained collective cell migration

Leclech

Barakat

2023

BioEssays

View full text Add to dashboard Cite

show abstract

“…(2) azimuthal shear flow as was shown in Figure 3. Successive radial inward flow and outward flow, caused by the action of centrifugal force against to viscoelastic force and the surface tension force, represent the part of the mechanical standing waves well elaborated on the model system such as CCM of a confluent cell monolayer [6,34].…”

Section: Roles Of Cell Normal and Shear Residual Stresses In The Appearance Of Csmmentioning

confidence: 99%

Viscoelasticity and cell jamming state transition

Pajić‐Lijaković

Milivojević

2021

Preprint

View full text Add to dashboard Cite

Although collective cell migration (CCM) is a highly coordinated migratory mode, perturbations in the form of jamming state transitions and vice versa often occur even in 2D. These perturbations are involved in various biological processes, such as embryogenesis, wound healing and cancer invasion. CCM induces accumulation of cell residual stress which has a feedback impact to cell packing density. Density-mediated change of cell mobility influences the state of viscoelasticity of multicellular systems and on that base the jamming state transition. Although a good comprehension of how cells collectively migrate by following molecular rules has been generated, the impact of cellular rearrangements on cell viscoelasticity remains less understood. Thus, considering the density driven evolution of viscoelasticity caused by reduction of cell mobility could result in a powerful tool in order to address the contribution of cell jamming state transition in CCM and help to understand this important but still controversial topic. In addition, five viscoelastic states gained within three regimes: (1) convective regime, (2) conductive regime, and (3) damped-conductive regime was discussed based on the modeling consideration with special emphasis of jamming and unjamming states.

show abstract

“…These strains lead to the generation of corresponding shear and normal stresses, their short-time relaxations and the long-time accumulation of cell residual stresses (Pajic-Lijakovic and Milivojevic, 2020b;2021a). The main characteristic of propagative mechanical waves is that (1) cell normal residual stress component σ cxx and corresponding strain rate are in phase quadrature, (2) normal stress component is always tensional, and (3) velocity and cell tractions are uncorrelated (Serra-Picamal et al, 2012; Petrolli et al, 2021). These characteristics of the propagative waves pointed to the Zener model suitable for the viscoelastic solid as was discussed by Pajic-Lijakovic and Milivojevic (2020c).…”

Section: Free Expansion Of Cell Monolayer: the Generation Of Forward And Backward Flowsmentioning

confidence: 99%

“…In the transient sub-regime, the cell velocity tends to zero, i.e. and volume fraction of cells in passive (non-contractile) state increases from 0 to 1. The corresponding velocity correlation length is approximately equal to the single-cell size (Petrolli et al, 2021). Consequently, this sub-regime can be treated as the pseudo-phase transition between active (migrating) cell state to passive (resting) cell state obtained under constant cell packing density (Pajic-Lijakovic and Milivojevic, 2019a; 2020a).…”

Section: Collision Between Forward and Backward Flows: The Cell Packing Density Increasementioning

confidence: 99%

The role of viscoelasticity in long-time cell rearrangement

Pajić‐Lijaković

Milivojević

2021

Preprint

View full text Add to dashboard Cite

Although collective cell migration (CCM) is a highly coordinated and ordered migratory mode, perturbations in the form of mechanical waves appear even in 2D. These perturbations caused by the viscoelastic nature of cell rearrangement are involved in various biological processes, such as embryogenesis, wound healing and cancer invasion. The mechanical waves, as a product of the active turbulence occurred at low Reynolds number, represent an oscillatory change in cell velocity and the relevant rheological parameters. The velocity oscillations, in the form of forward and backward flows, are driven by: viscoelastic force, surface tension force, and traction force. The viscoelastic force represents a consequence of inhomogeneous distribution of cell residual stress accumulated during CCM. This cause-consequence relation is considered on a model system such as the cell monolayer free expansion. The collision of forward and backward flows causes an increase in cell packing density which has a feedback impact on the tissue viscoelasticity and on that base influences the tissue stiffness. The evidence of how the tissue stiffness is changed near the cell jamming is conflicting. To fill this gap, we discussed the density driven change in the tissue viscoelasticity by accounting for the cell pseudo-phase transition from active (contractile) to passive (non-contractile) state appeared near cell jamming in the rheological modeling consideration.

show abstract

Oscillations in collective cell migration

Cited by 10 publications

References 104 publications

Physiological ramifications of constrained collective cell migration

Physiological ramifications of constrained collective cell migration

Viscoelasticity and cell jamming state transition

The role of viscoelasticity in long-time cell rearrangement

Contact Info

Product

Resources

About