Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1

Yang, Xin; Jiao, Ye; Zhang, Yingying; Sun, Meng; Gao, Yingzhen; Zhou, Yan; Xiao, Heng; Ren, Jing; Zhou, Zhinan; Zhai, Yuanfang; Song, Bin; Zhang, Ling; Kong, Pengzhou

doi:10.1016/j.biopha.2024.116367

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116367

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Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1

Xin Yang,

Ye Jiao,

Yingying Zhang

et al.

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Cited by 1 publication

References 31 publications

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Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

Du,

Shui,

Chen

et al. 2024

CIMB

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Neuraminidases catalyze the desialylation of cell-surface glycoconjugates and play crucial roles in the development and function of tissues and organs. In both physiological and pathophysiological contexts, neuraminidases mediate diverse biological activities via the catalytic hydrolysis of terminal neuraminic, or sialic acid residues in glycolipid and glycoprotein substrates. The selective modulation of neuraminidase activity constitutes a promising strategy for treating a broad spectrum of human pathologies, including sialidosis and galactosialidosis, neurodegenerative disorders, cancer, cardiovascular diseases, diabetes, and pulmonary disorders. Structurally distinct as a large family of mammalian proteins, neuraminidases (NEU1 through NEU4) possess dissimilar yet overlapping profiles of tissue expression, cellular/subcellular localization, and substrate specificity. NEU1 is well characterized for its lysosomal catabolic functions, with ubiquitous and abundant expression across such tissues as the kidney, pancreas, skeletal muscle, liver, lungs, placenta, and brain. NEU1 also exhibits a broad substrate range on the cell surface, where it plays hitherto underappreciated roles in modulating the structure and function of cellular receptors, providing a basis for it to be a potential drug target in various human diseases. This review seeks to summarize the recent progress in the research on NEU1-associated diseases and highlight the mechanistic implications of NEU1 in disease pathogenesis. An improved understanding of NEU1-associated diseases should help accelerate translational initiatives to develop novel or better therapeutics.

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Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

Du,

Shui,

Chen

et al. 2024

CIMB

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Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1

Cited by 1 publication

References 31 publications

Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

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