Osler-Weber-Rendu syndrome complicated with pulmonary arteriovenous malformation: A case report and review of literatures

Wang, Kuanyu; Chen, Jen-Chih; Hsu, Jane-Yi

doi:10.4103/1011-4564.158695

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…[ 4 5 ] The pulmonary AVMs show a female predominance with a varied presentation from asymptomatic to serious complications such as development of right-to-left shunt leading to hypoxemia, paradoxical embolism resulting in cerebral stoke as well as cerebral abscess, neurological deficits, and massive hemoptysis. [ 6 7 ] Features of pulmonary artery hypertension along with dilated hepatic veins and supra hepatic portions of inferior vena cava were seen in our patient, as shown in Figure 3 . The occurrence of telangiectasias and AVMs in the gastrointestinal (GI) tract apart from skin makes the patient vulnerable to bleeding, and internal GI tract telangiectasias can bleed in one-third of patients.…”

Section: Discussionsupporting

confidence: 56%

A case report on uneventful anticoagulation and persistence of Type 1 Respiratory Failure post severe COVID-19 infection in a patient of Osler–Weber–Rendu syndrome

Daga

Gautam

Mawari

et al. 2022

Journal of Family Medicine and Primary Care

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A BSTRACT The SARS-CoV-2 pandemic has led researchers worldwide to study the patterns of association of SARS-CoV-2 with different diseases, which have been a prime focus of medical literature. Osler–Weber–Rendu syndrome, also known as hereditary hemorrhagic telangiectasia (HHT), is a rare genetic disorder in which patients present with recurrent epistaxis, nostril manipulations, and multiple arteriovenous malformations (AVMs) along with telangiectasias involving internal organs and mucocutaneous areas. In addition, these AVMs are prone to bleeding or act as a nidus for thrombus formation, apart from other serious complications, such as chronic hypoxemia, anemia, pulmonary artery hypertension, heart failure, and cerebrovascular accidents. Here, we present a case report of a patient who presented with acute onset respiratory complaints, had multiple episodes of epistaxis in the past, and was later diagnosed with HHT as per Curaçao criteria in our hospital. Doppler ultrasound over the left calf region showed an AVM. Contrast-enhanced computed tomography (CECT) angiography of the chest and abdomen revealed multiple pulmonary and hepatic AVMs along with splenic and uterine telangiectasias and malformations, who on acquiring severe COVID-19 infection developed complications such as anemia, pulmonary artery hypertension, sepsis, acute kidney injury, and post-COVID-19 persistence of Type 1 respiratory failure. Furthermore, the risk-benefit ratio of anticoagulation therapy in such patients with COVID-19 infection is tricky and challenging. However, our patient was prophylactically anti-coagulated with enoxaparin for 12 days with an uneventful outcome.

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Section: Discussionsupporting

confidence: 56%

A case report on uneventful anticoagulation and persistence of Type 1 Respiratory Failure post severe COVID-19 infection in a patient of Osler–Weber–Rendu syndrome

Daga

Gautam

Mawari

et al. 2022

Journal of Family Medicine and Primary Care

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A case of pulmonary arteriovenous malformation in the setting of Rendu Osler Weber syndrome

Nikolaou

Rafailidis

Κάρτας

et al. 2021

Radiology Case Reports

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Rendu Osler Weber syndrome is a rare disorder, in which arteriovenous malformations are a hallmark feature. We describe the case of a 77-year-old female patient who presented with dyspnea, recurrent epistaxis, and signs of right ventricular heart failure, along with hypoxia and severe anemia. Several imaging modalities facilitated diagnostic workup. The computed tomography revealed an area of pulmonary arteriovenous malformation. Visceral involvement, along with clinical criteria and medical history, established the diagnosis of Rendu Osler Weber syndrome. The patient was scheduled for embolization of the PAVM soon after the diagnosis. Proper imaging, guided by clinical suspicion can be extremely helpful in diagnosing and treating this rare entity.

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Osler-Weber-Rendu syndrome complicated with pulmonary arteriovenous malformation: A case report and review of literatures

Cited by 2 publications

References 10 publications

A case report on uneventful anticoagulation and persistence of Type 1 Respiratory Failure post severe COVID-19 infection in a patient of Osler–Weber–Rendu syndrome

A case report on uneventful anticoagulation and persistence of Type 1 Respiratory Failure post severe COVID-19 infection in a patient of Osler–Weber–Rendu syndrome

A case of pulmonary arteriovenous malformation in the setting of Rendu Osler Weber syndrome

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