Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging

Foster, April; Chami, Cecile El; O’Neill, CA; Watson, Rachel

doi:10.1111/acel.13058

Cited by 16 publications

(12 citation statements)

References 36 publications

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“…nih.gov/gene/). However, based on the immunohistochemical study, the taurine transporter is highly expressed in epidermis, but not dermis, among the skin layers, 39,40 indicating that the location of the taurine transporter may be involved.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Inconsistently, the concentration of NMT in skin is low, while skin might averagely express the taurine transporter gene according to the database for gene expression (). However, based on the immunohistochemical study, the taurine transporter is highly expressed in epidermis, but not dermis, among the skin layers, , indicating that the location of the taurine transporter may be involved.…”

Section: Resultsmentioning

confidence: 99%

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In Vivo and In Vitro Study of N-Methyltaurine on Pharmacokinetics and Antimuscle Atrophic Effects in Mice

et al. 2020

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Various types of seaweed are potential functional foods as they contain multiple bioactive compounds. N-Methyltaurine (NMT) is a taurine derivative metabolite found in a type of red algae. The functional actions of NMT in mammalian animals have not been investigated, but the parent compound, taurine, possesses a variety of cellular actions. To explore the beneficial role of NMT in animals, the present study analyzed the effect of NMT against glucocorticoid-induced skeletal muscle atrophy. Glucocorticoids are one of the major causes of pathological muscle atrophy. Initially, we assessed the bioavailability of ingested NMT by determining its concentration in mouse blood. The bioavailability of orally administered NMT was found to be 96.1% that of intravenously administered NMT. Mice maintained on water containing 0.5% NMT for several days lead to the distribution of the taurine derivative to various tissues, including skeletal muscles. Like taurine, the delivery of NMT to skeletal muscles or myoblast cells is cytoprotective. The treatment with NMT prevents dexamethasone-induced atrophy of myotubes derived from C2C12 cells. Similarly, the addition of 0.5% NMT to drinking water attenuates dexamethasone-mediated reduction in muscle mass of the treated mice. The present study supports the hypothesis that orally administered NMT partially reverses skeletal muscle atrophy.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In Vivo and In Vitro Study of N-Methyltaurine on Pharmacokinetics and Antimuscle Atrophic Effects in Mice

et al. 2020

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“…Human epidermal keratinocytes actively proliferate and differentiate to maintain the integrity of skin. However, keratinocytes have a finite lifespan and aged cells show reduced cell division and senescence phenotypes 60 . This sometimes makes it difficult for aged people to replenish the damaged regions of their skin 61 .…”

Section: Resultsmentioning

confidence: 99%

Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

Lee

Lee²,

Kim

2020

Sci Rep

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Active ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants. In this study, we examined whether a mixture of plant extracts obtained from agrimonia, houttuynia, licorice, peony, and phellodendron (hereafter AHLPP), which are well-known for their effects on skin, could affect skin barrier function, inflammation, and aging in human skin cells. We also determined whether AHLPP extracts sterilized using γ-irradiation (to avoid preservatives) retained their skin cell regulating activity. The AHLPP mixture could downregulate representative pro-inflammatory cytokines including IL 1-β and IL 7. Procollagen peptide synthesis was also increased by AHLPP treatment along with mRNA upregulation of barrier proteins such as filaggrin and desmoplakin. The AHLPP mixture showed an anti-aging effect by significantly upregulating telomerase activity in human keratinocytes. We further observed TERT upregulation and CDKN1B downregulation, implying a weakening of pro-aging signal transduction. Co-cultivation of a hydrogel polymer containing the AHLPP mixture with human skin cells showed an alteration in skin-significant genes such as FLG, which encodes filaggrin. Thus, the AHLPP mixture with or without γ-irradiation can be utilized for skin protection as it alters the expression of some significant genes in human skin cells.

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“…An in vivo study using taurine transporter knockout mice showed that epidermal taurine is involved in the photoprotection of skin (Rockel et al 2007 ). Recently, the study using human skin samples showed that epidermal keratinocytes possess osmolyte-mediated cell volume regulatory mechanisms, which is compromised in aging (Foster et al 2020 ). Furthermore, taurine has been shown to enhance the structure and function of tight junction in keratinocytes (El-Chami et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Age-related decline in the taurine content of the skin in rodents

et al. 2021

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Taurine, a sulfur-containing amino acid, occurs at high concentrations in the skin, and plays a role in maintaining the homeostasis of the skin. We investigated the effects of aging on the content and localization of taurine in the skin of mice and rats. Taurine was extracted from the skin samples of hairless mice and Sprague Dawley rats, and the taurine content of the skin was determined by high-performance liquid chromatography (HPLC). The results of the investigation revealed that the taurine content in both the dermis and epidermis of hairless mice declined significantly with age. Similar age-related decline in the skin taurine content was also observed in rats. In contrast, the taurine content in the sole remained unchanged with age. An immunohistochemical analysis also revealed a decreased skin taurine content in aged animals compared with younger animals, although no significant differences in the localization of taurine were observed between the two age groups. Supplementation of the drinking water of aged mice with 3% (w/v) taurine for 4 weeks increased the taurine content of the epidermis, but not the dermis. The present study showed for the first time that the taurine content of the skin decreased with age in mice and rats, which may be related to the impairment of the skin homeostasis observed with aging. The decreased taurine content of the epidermis in aged animals was able to be rescued by taurine supplementation.

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Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging

Cited by 16 publications

References 36 publications

In Vivo and In Vitro Study of N-Methyltaurine on Pharmacokinetics and Antimuscle Atrophic Effects in Mice

In Vivo and In Vitro Study of N-Methyltaurine on Pharmacokinetics and Antimuscle Atrophic Effects in Mice

Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

Age-related decline in the taurine content of the skin in rodents

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