Osmoreceptor Function among the Elderly

Mukherjee, Angshuman; Coni, Nicholas; Davison, Wilburt C.

doi:10.1159/000245460

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…The reason might be the thermal regulation system weakens with aging (Tian et al 2012). The elderly are less able to maintain homeostasis in response to environmental challenges (Mukherjee et al 1973;Goggins et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Effects of temperature on mortality in Hong Kong: a time series analysis

Chan

2014

Int J Biometeorol

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Although interest in assessing the impacts of hot temperature and mortality in Hong Kong has increased, less evidence on the effect of cold temperature on mortality is available. We examined both the effects of heat and cold temperatures on daily mortality in Hong Kong for the last decade (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011). A quasi-Poisson model combined with a distributed lag non-linear model was used to assess the non-linear and delayed effects of temperatures on cause-specific and age-specific mortality.Non-linear effects of temperature on mortality were identified. The relative risk of non-accidental mortality associated with cold temperature (11.1°C, 1 st percentile of temperature) relative to 19.4°C(25 th percentile of temperature) was 1.17 (95% confidence interval (CI): 1.04, 1.29) for lags 0-13. The relative risk of non-accidental mortality associated with high temperature (31.5°C, 99 th percentile of temperature) relative to 27.8°C (75 th percentile of temperature) was 1.09 (95% CI: 1.03, 1.17) for lags 0-3. In Hong Kong, extreme cold and hot temperatures increased the risk of mortality. The effect of cold lasted longer and greater than that of heat. People older than 75 years were the most vulnerable group to cold temperature, while people aged 65-74 were the most vulnerable group to hot temperature.Our findings may have implications for developing intervention strategies for extreme cold and hot temperatures.

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Section: Discussionmentioning

confidence: 99%

Effects of temperature on mortality in Hong Kong: a time series analysis

Chan

2014

Int J Biometeorol

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“…This association might be explained by an increase in blood viscosity during heat stress [7], which could predispose to ischemic stroke. The elderly are more prone to dehy dration due to a decline in the ability of the kidney to conserve water [ 18] as a result of a diminished renal tubular response to antidi uretic hormone (ADH) [19] and a decrease in the thirst drive [18]. However, we were unable to demonstrate a rise in hematocrit or albumin/globin ratio with increasing tem perature.…”

Section: Discussionmentioning

confidence: 57%

Environmental Temperature and Stroke in a Subtropical Climate

Woo

Kay

Nicholls³

1991

Neuroepidemiology

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The effect of environmental temperature on stroke occurrence in a subtropical climate was studied over a 1-year period by documenting the number of strokes (subdivided into cerebral infarct and intracerebral hemorrhage) admitted into a district hospital in Hong Kong at different temperatures. There was no significant correlation between the number of strokes (or its subtypes) per day per temperature category and the environmental minimum or maximum temperature. However, an association was present between the occurrence of cerebral infarcts and maximum temperature on the day of onset in elderly patients aged 70 years and above. Environmental temperature is not a strong risk factor for the occurrence of stroke in a subtropical climate.

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“…However, this observation is in agreement with several earlier reports. Diminished neurohypophyseal AVP release with age has been suggested by both human and animal experiments (Friedman et al, 1956;Friedman et aZ., 1963;Mukherjee et al, 1973), and blood concentrations of neurophysin have been reported to be significantly lower in elderly males (Legros, 1975). In contrast, Helderman et al (1976) found no difference in baseline AVP concentrations between young and old men.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Pain on Plasma Arginine Vasopressin Concentrations in Man

Kendler

Weitzman

Fisher

1978

Clinical Endocrinology

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The effect of pain on plasma AVP concentration in man has previously been studied only during major surgery with general anaesthesia. Plasma AVP concentration (pAVP) and plasma osmolality (pOsm) were measured in thirty-six patients seen in a surgical emergency department complaining of pain and in fifty-one control subjects. No significant difference in pOsm was found, but pAVP was significantly higher in the emergency room patients in pain (M +/- SEM = 4.94 +/- 0.98 pmol/1 compared to 2.31 +/- 0.32 pmol/1 in control subjects, P less than 0.01). In the control subjects, age was found to have a low but significant inverse correlation with pAVP (r = 0.37, P less than 0.01). Chronic smoking was associated with significant elevation of pAVP (3.81 +/- 0.99 pmol/1 in smokers vs. 1.89 +/- 0.28 pmol/1 in non-smokers, P less than 0.02). Neither smoking nor age could account for the difference in pAVP between the pain and control groups. Thus, pain is a non-osmolar factor capable of elevating AVP in conscious man.

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Osmoreceptor Function among the Elderly

Cited by 16 publications

References 6 publications

Effects of temperature on mortality in Hong Kong: a time series analysis

Effects of temperature on mortality in Hong Kong: a time series analysis

Environmental Temperature and Stroke in a Subtropical Climate

The Effect of Pain on Plasma Arginine Vasopressin Concentrations in Man

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