Osmotic and Nonosmotic Regulation of Arginine Vasopressin during Prolonged Endurance Exercise

Hew‐Butler, Tamara; Jordaan, Esme; Stuempfle, Kristin J.; Speedy, Dale B.; Siegel, Arthur J.; Noakes, Timothy D.; Soldin, Steven J.; Verbalis, Joseph G.

doi:10.1210/jc.2007-2336

Cited by 98 publications

(122 citation statements)

References 33 publications

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“…Regarding recent findings, an increased activity of vasopressin may contribute to the pathogenesis of EAH. 7,8 However, vasopressin showed no change in this race and the increase in extracellular water was neither related to post race vasopressin nor to the change in vasopressin. Likewise, vasopressin and urinary osmolality showed no relationship.…”

Section: Discussionmentioning

confidence: 78%

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Effect of a Multistage Ultraendurance Triathlon on Aldosterone, Vasopressin, Extracellular Water and Urine Electrolytes

et al. 2012

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Prolonged endurance exercise over several days induces increase in extracellular water (ECW). We aimed to investigate an association between the increase in ECW and the change in aldosterone and vasopressin in a multistage ultraendurance triathlon, the 'World Challenge Deca Iron Triathlon' with 10 Ironman triathlons within 10 days. Before and after each Ironman, body mass, ECW, urinary [Na(+)], urinary [K(+)], urinary specific gravity, urinary osmolality and aldosterone and vasopressin in plasma were measured. The 11 finishers completed the total distance of 38 km swimming, 1800 km cycling and 422 km running within 145.5 (18.8) hours and 25 (22) minutes. ECW increased by 0.9 (1.1) L from 14.6 (1.5) L prerace to 15.5 (1.9) L postrace (P < 0.0001). Aldosterone increased from 70.8 (104.5) pg/mL to 102.6 (104.6) pg/mL (P = 0.033); vasopressin remained unchanged. The increase in ECW was related neither to postrace aldosterone nor to postrace vasopressin. In conclusion, ECW and aldosterone increased after this multistage ultraendurance triathlon, but vasopressin did not. The increase in ECW and the increase in aldosterone were not associated.

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Section: Discussionmentioning

confidence: 78%

“…7,8 An interesting finding in multi-stage ultra-endurance performances is the increase in total body water. 9,10 It has been well documented that prolonged strenuous exercise over several consecutive days induced a progressive increase in extracellular water, plasma volume and total body water.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Multistage Ultraendurance Triathlon on Aldosterone, Vasopressin, Extracellular Water and Urine Electrolytes

et al. 2012

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“…Moreover, hormonal diseases such as adrenal insufficiency and hypothyroidism can be associated with low serum sodium. Athletes participating in competitive sports are also at high risk for hyponatremia, as a result of excess free water drinking and sweating [4] . SIADH is a disorder of impaired water excretion caused by an inability to suppress the secretion of antidiuretic hormone (ADH), and may be a result of CNS disturbances, malignancies, drugs, HIV infection or surgery [5] .…”

Section: Discussionmentioning

confidence: 99%

Late diagnosis of MDMA-related severe hyponatremia

Chang

Ger

Yang

2014

CRIM

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Introduction: 3, 4-methylenedioxymethamphetamine (MDMA) is a popular psychoactive amphetamine derivative with the potential to induce life-threatening hyponatremia. The absence of exposure history and typical toxidromes however make the prompt diagnosis of MDMA-induced hyponatremic coma difficult and easily overlooked.Case Report: A 24-year-old female presented to the emergency department with an altered mental status. Physical examinations, laboratory workup and brain imaging study were remarkable for severe hyponatremia (serum sodium 116 mmol/L) and diffuse brain edema only. Her family denied that she had used any illicit drugs. The diagnosis of MDMA-related hyponatremic coma was not made until six days later when toxicologic screen confirmed the presence of high concentration of MDMA (7,767 ng/ml) in the patient's urine. Conclusion:Our case demonstrates the difficulty in the correct diagnosis of MDMA-induced hyponatremic coma in the absence of MDMA exposure history and typical sympathomimetic effects. A high index of suspicion and prompt toxicological screen are thus important in the diagnosis of MDMA-related severe hypontremia.

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“…3 Another possible cause of the hyponatremia observed after the midpoint of the marathon run was a heat-and/or exercise-induced oversecretion of arginine vasopressin (AVP). 6 Thus, the peak high core temperature (39.4°C) that likely caused the triathlete to slow may also have stimulated a nonosmotic AVP secretion, leading to fluid retention and a dilutional hyponatremia. This presumption is supported by both the increased post-race urine osmolality (619 mOsm·kg ) acting to preserve blood sodium.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermic Fatigue Precedes a Rapid Reduction in Serum Sodium in an Ironman Triathlete: A Case Report

Laursen

Watson²,

Abbiss³

et al. 2009

International Journal of Sports Physiology and Performance

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Purpose:To monitor the hydration, core temperature, and speed (pace) of a triathlete performing an Ironman triathlon. Methods: A 35-year-old experienced male triathlete participated in the Western Australian Ironman triathlon on December 1, 2006. The participant was monitored for blood Na + concentration before the race (PRE), at the transitions (T1 and T2), halfway through the run (R21), and after the race (POST; 2hPOST). Core body temperature (T c ; pill telemetry) was recorded continuously, and running speed (s3 stride sensor) was measured during the run. Results: The participant completed the race in 11 h 38 min, in hot conditions (26.6 ± 5.8°C; 42 ± 19% rel. humidity). His T c increased from 37.0 to 38.6°C during the 57-min swim, and averaged 38.4°C during the 335-min bike (33.5 km·h

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Osmotic and Nonosmotic Regulation of Arginine Vasopressin during Prolonged Endurance Exercise

Cited by 98 publications

References 33 publications

Effect of a Multistage Ultraendurance Triathlon on Aldosterone, Vasopressin, Extracellular Water and Urine Electrolytes

Effect of a Multistage Ultraendurance Triathlon on Aldosterone, Vasopressin, Extracellular Water and Urine Electrolytes

Late diagnosis of MDMA-related severe hyponatremia

Hyperthermic Fatigue Precedes a Rapid Reduction in Serum Sodium in an Ironman Triathlete: A Case Report

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