2018
DOI: 10.3949/ccjm.85a.17020
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Osmotic demyelination syndrome due to hyperosmolar hyperglycemia

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Cited by 9 publications
(15 citation statements)
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“…Although ODS has been reported to rarely develop in HHS [10][11][12][13][14][15][16][17][18][19][20][21][22], fewer reports have described development of ODS in HHS with hypernatremia [10-12, 15, 16], and causes of ODS development have yet to be clarified in terms of marked hyperosmolarity or changes in osmotic pressure associated with treatment. Within 7 days of onset, findings of ODS are not detectable on MRI [24,25].…”
Section: Discussionmentioning
confidence: 99%
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“…Although ODS has been reported to rarely develop in HHS [10][11][12][13][14][15][16][17][18][19][20][21][22], fewer reports have described development of ODS in HHS with hypernatremia [10-12, 15, 16], and causes of ODS development have yet to be clarified in terms of marked hyperosmolarity or changes in osmotic pressure associated with treatment. Within 7 days of onset, findings of ODS are not detectable on MRI [24,25].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, HHS is a life-threatening endocrine emergency (mortality rate, 10-50%) associated with marked hyperglycemia and severe dehydration [9]. HHS may develop to ODS [10][11][12][13][14][15][16][17][18][19][20][21][22], and some cases have been reported in association with hypernatremia [10-12, 15, 16].…”
Section: Introductionmentioning
confidence: 99%
“…However, ODS has rarely been described in the context of diabetes mellitus. There have been cases of hyperglycemic patients developing ODS, both associated with rebound hypernatremia [5,11] and with normal sodium levels [6,8,[12][13][14][15]. In 2012, Hegazi and Mashankar reported the case of a diabetic female with CPM in association with hypernatremia caused by a hyperosmolar hyperglycemic state (HHS) who was treated conservatively [5].…”
Section: Discussionmentioning
confidence: 99%
“…ODS is characterized by progressive lethargy, quadriparesis, dysarthria, ophthalmoplegia, dysphasia, ataxia, and reflex changes. Clinical symptoms of extrapontine myelinolysis are variable [5]. Although the pathogenesis of ODS is not clearly understood, ODS is caused by a sudden shrinkage of brain cells (particularly oligodendrocytes), and demyelination due to a rapid change in serum osmolality [6].…”
Section: Discussionmentioning
confidence: 99%