Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling
Ana Monfort-Vengut,
Natalia Sanz-Gómez,
Sandra Ballesteros-Sánchez
et al.
Abstract:Ion homeostasis is critical for numerous cellular processes, and disturbances in ionic balance underlie diverse pathological conditions, including cancer progression. Targeting ion homeostasis is even considered as a strategy to treat cancer. However, very little is known about how ion homeostasis may influence anticancer drug response. In a genome-wide CRISPR-Cas9 resistance drug screen, we identified and validated the master osmostress regulator WNK1 kinase as a modulator of the response to the mitotic drug … Show more
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