Osmotically regulated asymmetric capsular system for sustained delivery of indomethacin

Jain, Dinesh Kumar; Darwhekar, G. N.; Solanki, Shailendra Singh; Sharma, Ravi Kumar

doi:10.1007/s40005-012-0050-3

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…This is consistent with our assumption given to calculate the absorption cross section of graphene plasmons in Figure 1. The same performance (R % 0) can be obtained when the frequency of laser and ω max lie in the range of 1800-2500 cm À1 [34,35] or 0.22-0.31 eV. It means that the Fermi energy varies from 1.3 to 1.8 eV if the diameter of graphene plasmon is fixed at 120 nm.…”

Section: Optical Properties and Photothermal Effects Of Graphene Plas...mentioning

confidence: 59%

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Phan

Ngân

Nga

et al. 2022

Physica Rapid Research Ltrs

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A theoretical approach to quantitatively determine the photothermally driven enhancement of molecular mobility of graphene‐indomethacin mixtures under infrared laser irradiation is proposed. Graphene plasmons absorb incident electromagnetic energy and dissipate them into heat. The absorbed energy depends on optical properties of graphene plasmons, which are sensitive to structural parameters, and concentration of plasmonic nanostructures. By using theoretical modelling, temperature gradients of the bulk drug with different concentrations of graphene plasmons are calculated. From these, the temperature dependence of structural molecular relaxation and diffusion of indomethacin are determined and how the heating process significantly enhances the drug mobility is found out.

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Section: Optical Properties and Photothermal Effects Of Graphene Plas...mentioning

confidence: 59%

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Phan

Ngân

Nga

et al. 2022

Physica Rapid Research Ltrs

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show abstract

“…1. The same performance (R ≈ 0) can be obtained when the frequency of laser and ω max lie in the range of 1800-2500 cm -1 [34,35] or 0.22-0.31 eV. It means that the Fermi energy varies from 1.3 eV to 1.8 eV if the diameter of graphene plasmon is fixed at 120 nm.…”

mentioning

confidence: 56%

“…Based on Ref. [34,35], the transmission of indomethacin at 806.6 cm -1 is about 97 %. It suggests that R and the absorption of pure indomethacin are relatively small.…”

mentioning

confidence: 99%

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Phan,

Ngan,

Nga

et al. 2021

Preprint

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We propose a theoretical approach to quantitatively determine the photothermally driven enhancement of molecular mobility of graphene-indomethacin mixtures under infrared laser irradiation. Graphene plasmons absorb incident electromagnetic energy and dissipate them into heat. The absorbed energy depends on optical properties of graphene plasmons, which are sensitive to structural parameters, and concentration of plasmonic nanostructures. By using theoretical model, we calculate temperature gradients of the bulk drug with different concentrations of graphene plasmons. From these, we determine the temperature dependence of structural molecular relaxation and diffusion of indomethacin and find how the heating process significantly enhances the drug mobility.

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“…Moreover, the peak at 1468 cm −1 corresponds to O-CH3 deformation and the peaks in the region of 708 cm −1 correspond to the presence of aromatic ring of indomethacin, as illustrated in Figure 7d,e [49,50]. A broad shoulder better evidenced in Figure 7b,c in the region 3400-3200 cm −1 may be assigned to the presence of N-H stretching vibrations of pyrrole ring [51,52]. The peak at 1566 cm -1 is attributed mainly to the intercycle C-C stretching vibration in PPy and the band centered at 1163 cm −1 can be associated with C-N stretch while the peak at 957 cm −1 is due to ring stretch from pyrrole [53,54].…”

Section: Characterization Of Indo Doped Ppy Coatingsmentioning

confidence: 82%

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

Golgovici

Cârlan

Popescu

et al. 2020

Metals

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There is an increased interest in the use of the deep eutectic solvents (DESs) as electrolytic media for electrochemical synthesis of conducting polymers, which could influence their characteristics. Moreover, the polypyrrole layers represent an attractive route for pharmaceutical drug release. The paper presents several experimental results regarding the electrodeposition of polypyrrole and of polypyrrole-indomethacin coatings on nickel-chromium NiCr alloy substrates widely used in dentistry, involving DES-based electrolytes, namely eutectic mixtures of choline chloride and malonic acid. This type of electrolyte also allowed an enhanced dissolution of indomethacin as compared to aqueous ones. The electropolymerization process has been investigated by cyclic voltammetry and chronoamperometry. The obtained indomethacin containing polymeric coatings have been thoroughly characterized involving scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, contact angle measurements in simulated body fluid (SBF) and indomethacin release studies. Adherent and uniform polypyrrole-indomethacin layers have been obtained on NiCr alloy substrates. The release tests showed that the polypyrrole coatings containing indomethacin may deliver the drug molecules for longer periods of at least 17 days. The maximum released amount was around 99.6% suggesting these layers may act as an active reservoir for indomethacin. Kinetics analysis based on the Korsmeyer–Peppas model suggested the diffusion of the drug out of the polymer layer as the most probable mechanism governing the release.

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Osmotically regulated asymmetric capsular system for sustained delivery of indomethacin

Cited by 8 publications

References 13 publications

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Tailoring Drug Mobility by Photothermal Heating of Graphene Plasmons

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

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