Osmundacetone Alleviates Cerebral Ischemia–Reperfusion Injury in Rats

Li, Bowen; Yu, Wentao; Yang, Lan

doi:10.1248/bpb.b23-00326

Cited by 3 publications

(3 citation statements)

References 27 publications

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“… Rhein, an anthraquinone, exerts neuroprotective effects by regulating the NRF2/SLC7A11/GPX4 pathway, inhibiting ferroptosis during IRI following a stroke in murine models [ 84 ]. Osmundacetone [ 85 ], a natural antioxidant, and Ruscogenin [ 86 ], a steroidal sapogenin, have shown effectiveness in reducing the IRI in stroke models in rats by increasing the concentration of Nrf2 mRNA, HO-1, and NQO1. Osmundacetone has also decreased Keap1 and caspase 3 [ 85 ].…”

Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning

confidence: 99%

“… Osmundacetone [ 85 ], a natural antioxidant, and Ruscogenin [ 86 ], a steroidal sapogenin, have shown effectiveness in reducing the IRI in stroke models in rats by increasing the concentration of Nrf2 mRNA, HO-1, and NQO1. Osmundacetone has also decreased Keap1 and caspase 3 [ 85 ]. Crebabine, an alkaloid with neuroprotective effects, was shown to be effective in a murine model of stroke, reducing cerebral damage by suppressing NADPH and NOX2 activity and through the inhibition of the NF-κB and MAPK pathways [ 87 ].…”

Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning

confidence: 99%

Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning

confidence: 99%

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Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Briones-Valdivieso,

Briones,

Orellana-Urzúa

et al. 2024

Biomedicines

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Stroke is a major contributor to global mortality and disability. While reperfusion is essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, a paradoxical injury primarily caused by oxidative stress, inflammation, and blood–brain barrier disruption. An oxidative burst inflicts marked cellular damage, ranging from alterations in mitochondrial function to lipid peroxidation and the activation of intricate signalling pathways that can even lead to cell death. Thus, given the pivotal role of oxidative stress in the mechanisms of cerebral ischemia-reperfusion injury, the reinforcement of the antioxidant defence system has been proposed as a protective approach. Although this strategy has proven to be successful in experimental models, its translation into clinical practice has yielded inconsistent results. However, it should be considered that the availability of numerous antioxidant molecules with a wide range of chemical properties can affect the extent of injury; several groups of antioxidant molecules, including polyphenols, carotenoids, and vitamins, among other antioxidant compounds, can mitigate this damage by intervening in multiple signalling pathways at various stages. Multiple clinical trials have previously been conducted to evaluate these properties using melatonin, acetyl-L-carnitine, chrysanthemum extract, edaravone dexborneol, saffron, coenzyme Q10, and oleoylethanolamide, among other treatments. Therefore, multi-antioxidant therapy emerges as a promising novel therapeutic option due to the potential synergistic effect provided by the simultaneous roles of the individual compounds.

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Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning

confidence: 99%

Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning

confidence: 99%

See 1 more Smart Citation

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Briones-Valdivieso,

Briones,

Orellana-Urzúa

et al. 2024

Biomedicines

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Artemisinin attenuates perinatal inflammation and consequent oxidative stress in oligodendrocyte precursor cells by inhibiting IRAK-4 and IRAK-1

Zhang,

Lu,

et al. 2024

International Immunopharmacology

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Isolation and Antioxidant Mechanism of Polyphenols from Sanghuangporous vaninii

Liu,

Wang,

Chen

et al. 2024

Antioxidants

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Sanghuangporous vaninii, as an edible and medicinal macrofungus, represents a high source of polyphenols with considerable antioxidant activities. However, due to the significant differences in polyphenol content and bioactivity caused by different cultivation substrates, its antioxidant mechanism has not been fully determined. In this paper, five groups of S. vaninii fruiting bodies were collected from cultivation substrates from different areas. The ethanol extracts of mulberry sawdust from Haining City (HNMS) had the highest polyphenol content, as well as excellent antioxidant activity. HNMS3, a polyphenol component with promising antioxidant capacity, was further isolated through optimization with different extractants, silica gel column chromatography, and thin layer chromatography analysis. UPLC-Q-TOF-MS analysis showed that HNMS3 was composed of 33 compounds, corresponding to 257 targets of oxidative stress by network pharmacology analysis, which were strongly associated with mental health and neurodegenerative diseases. Protein–protein interaction and molecular docking analysis indicated that eight hub genes (PPARG, IL-6, STAT3, PTGS2, SRC, MTOR, ERS1, and EGFR) are attributed to the regulation of the key compounds hispidin, inoscavin A, inoscavin_C, and phellibaumin B. Consequently, this study obtains S. vaninii polyphenolic component HNMS3 with excellent antioxidant capacity, simultaneously revealing its potential antioxidant mechanisms, providing new insights into the application of S. vaninii.

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Osmundacetone Alleviates Cerebral Ischemia–Reperfusion Injury in Rats

Cited by 3 publications

References 27 publications

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Artemisinin attenuates perinatal inflammation and consequent oxidative stress in oligodendrocyte precursor cells by inhibiting IRAK-4 and IRAK-1

Isolation and Antioxidant Mechanism of Polyphenols from Sanghuangporous vaninii

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