Osseointegration: An Update

Parithimarkalaignan, S.; Padmanabhan, T. V.

doi:10.1007/s13191-013-0252-z

Cited by 220 publications

(151 citation statements)

References 16 publications

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“…In consequence, the body usually responds by forming a nonadherent fibrous tissue (through a process called fibrosis) around the surface of the material, and progressively, they are completely encapsulated by such layer. Several works have reported the severe reduction in the mechanical strength of a fibrous encapsulated implant compared with a properly osseointegrated implant [1]. On the other hand, these problems can be worsened by bacterial, viral, or fungal infections occurring around the implant.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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“…Osseointegration success is determined by the incorporation of the woven bone and the bone mass' adaptation to bearing a load (2).…”

Section: Introductionmentioning

confidence: 99%

Chronic Periodontitis and RANKL/OPG Ratio in Peri-Implant Mucosae Inflammation

et al. 2018

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History of chronic periodontitis (CP) is a risk factor for oseointegration failure. The osteoclastogenesis system (RANK, RANKL and OPG) is critical for bone homeostatic control. We investigated the levels of OPG and RANKL in peri-implant tissues from volunteers with and without a history of CP and their association with mucosae inflammation. This is a single-blind case-contro study. Diagnosis of a history of CP and peri-implant examination was performed on 46 volunteers, divided into control (without history of CP, n=26) and CP group (with history of CP, n=20). Gingival biopsies were harvested during implant exposure. Quantitative PCR evaluated OPG/RANKL mRNA expressions. OPG and RANKL proteins were analyzed by western blot and immunohistochemistry assay. The chi-square test analyzed the significance of nominal variables between groups while continuous variables were analyzed by T-test or Mann-Whitney test, after Shapiro-Wilk test evaluation. The 2-ΔΔCT Livak method calculation evaluated the gene expression. Values of p<0.05 were considered statistically significant. Volunteers with CP history had 23 times higher chance of developing mucosae inflammation. High mucosae levels of RANKL (p=0.04) and RANKL/OPG (p=0.001) mRNA expressions were observed in CP group. CP volunteers showed increased RANKL protein levels in opposition to decreased OPG expression. Even without active periodontitis, volunteers with a history of CP had elevated gingival levels of RANKL/OPG and higher correlation with peri-implant mucosae inflammation and implant loss. C h r o n i c P e r i o d o n t i t i s a n d R

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“…20 Since a long time, it has advocated that a two-stage surgical procedure for load-free and submerged healing is a prerequisite to enclose predictable osseointegration. 21 Challenges facing patients and clinicians are inconvenience, discomfort, and anxiety that are related with the waiting period. Consequently, implant loading later after placement was attempted and has gained popularity among clinicians.…”

Section: Introductionmentioning

confidence: 99%

Three-year Prospective Evaluation of Immediately Loaded Mandibular Implant Overdentures retained with Locator Attachments

Al-Dharrab

2017

The Journal of Contemporary Dental Practice

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Introduction: Immediate implant-loading protocol has progressed because of various clinical advantages offered by this treatment approach. However, available studies on edentulous patients are still few compared to those in which delayed implantloading protocol was applied.Aim: This prospective study was to evaluate the implant survival rate and the peri-implant tissue response in a group of patients who received two unsplinted immediately loaded dental implants in the mandibular anterior region to retain a complete overdenture using locator attachments. Materials and methods:A total of 24 edentulous patients with a mean age of 63.4 years were involved in this study following certain inclusion criteria. All patients received a new set of complete dentures before implant positioning. Two Prima Connex tapered implants were put in the interforaminal area of the mandible with a flapless surgical procedure, and the prefabricated dentures were immediately retained with a zest locator attachment. Clinical and radiographic records of the patients were reviewed immediately after placement of the implant, at 3 months, and at 1, 2, and 3 years following fixture installation. The obtained data were analyzed using paired samples t-test and the Wilcoxon signed-rank test at 0.05 significance level. Results:At 3 years, all implants had osseointegrated with a 100% survival rate. In addition, the total mean marginal bone change was −0.89 ± 0.14 mm, and the mean periotest value was −7.631 ± 0.921. Conclusion:Results of this study propose that immediate loading of mandibular implant overdentures that are retained with locator attachments was a feasible treatment alternative for this particular group of patients. Three-year Prospective Evaluation of Immediately Loaded Mandibular Implant Overdentures retained with Locator AttachmentsAyman Al-Dharrab

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Osseointegration: An Update

Cited by 220 publications

References 16 publications

Laser Surface Texturing of Polymers for Biomedical Applications

Laser Surface Texturing of Polymers for Biomedical Applications

Chronic Periodontitis and RANKL/OPG Ratio in Peri-Implant Mucosae Inflammation

Three-year Prospective Evaluation of Immediately Loaded Mandibular Implant Overdentures retained with Locator Attachments

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