Osseointegration enhancement by controlling dispersion state of carbonate apatite in polylactic acid implant

Zhang, Cheng; Hayashi, Koichiro; Ishikawa, Kunio

doi:10.1016/j.colsurfb.2023.113588

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…In addition, the presence of both mature and osteoid bone has been observed, and active bone remodeling has been reported [17]. Many studies of CA in dental practice have been reported in relation to implant surgery [18][19][20]. There are several resorbable bone grafting materials, but nothing has been actively used in the treatment of alveolar clefts [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite

Kibe,

Nakazono,

Yamashita

et al. 2023

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Autologous bone grafting is the primary method for treating alveolar clefts. However, bone grafting materials are desired as alternatives to autogenous bone to reduce surgical invasiveness. Here, we present an animal study evaluating the effect of carbonate apatite (CA) on the spontaneous eruption of permanent teeth. The bone grafting materials included CA, natural bovine bone (BB), and hydroxyapatite (HA). In 15 8-week-old male beagle dogs, the left mandibular deciduous premolars (DP) two and three were extracted and subsequently filled with CA, BB, and HA. The animals were euthanized after a predetermined number of days, and samples were collected for microcomputed tomography and histological evaluation. Spontaneous eruption of the succeeding permanent teeth (P3 and P4) was observed in the CA group at 14 weeks. Delayed eruption of the succeeding permanent teeth was observed in the BB and HA groups. CA could serve as a viable alternative to autogenous bone for treating alveolar clefts.

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