Osseointegration—Molecular events at the bone–implant interface: A review

Chug, Ashi; Shukla, Sagrika; Mahesh, Lanka; Jadwani, Sanjay

doi:10.1016/j.ajoms.2012.01.008

Cited by 44 publications

(49 citation statements)

References 37 publications

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“…SF coating improves the surface roughness of UHMWPE, and it is evident that rough surface enhances the process of cell attachment with rich filopodia extension. 39,40 The increased surface roughness even outweighs the enhanced wettability for the adhesion and proliferation of fibroblast cells. 18 Besides, as a versatile biomaterial in tissue engineering, SF is capable of supporting the proliferation and differentiation of BMSCs along the osteogenic lineage.…”

mentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

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Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM) and attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8) assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT) analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF coating. This study showed that the method loading VEGF on UHMWPE by SF coating played an effective role on the biological performance of UHMWPE and displayed a great potential application for anterior cruciate ligament reconstruction.

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mentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

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“…As discussed in previous sections, nano-rough surfaces, particularly nanotubular Ti promotes bone cell functions, leading to improved osseointegration as compared to conventional and micro-machined Ti surfaces [70,104]. Reports have indicated that TNT surfaces' ability to initially absorb high amount of vitronectin (protein that facilitates osteoblast adhesion) from serum is the key for this morphology to be most suitable for bone implant applications [103]. Besides the surface topography, bone cell adhesion/proliferation can also be enhanced by incorporating bone forming species like: growth factors, biopolymers and hydroxyapatite (HAP) [9].…”

Section: Implant Integrationmentioning

confidence: 95%

“…This is essential when it comes to bone implants and prevents implant loosening/micromotion, which can contribute to implant failure [103]. As discussed in previous sections, nano-rough surfaces, particularly nanotubular Ti promotes bone cell functions, leading to improved osseointegration as compared to conventional and micro-machined Ti surfaces [70,104].…”

Section: Implant Integrationmentioning

confidence: 95%

Titania Nanotubes for Local Drug Delivery from Implant Surfaces

Gulati

Kogawa

Maher

et al. 2015

Electrochemically Engineered Nanoporous Materials

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The principal challenge for bone therapy is to deliver an effective dose of therapeutic agent (for example antibiotic or anti-cancer drug) to the affected site within bone, while sparing other organs. The solution to this dilemma is to deliver drug locally within the bone; hence various surface/therapeutic modifications of the conventional bone implants have been suggested to achieve this. Implants composed of biocompatible materials and loaded with active therapeutics thus provide one possible option for effective bone therapy. This chapter showcases the challenges that an electrochemically nano-engineered bone implant based on titania nanotubes must overcome to survive and deliver therapeutics in conditions such as infections and cancer of bone. The fabrication of titania nanotubes, the therapeutic loading and release, ex vivo and in vivo investigations; all are reviewed in terms of effectiveness for therapeutic action. Also discussed are the potential advances of titania nanotube technology and the future research directions to address additional clinical problems.

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“…3,4 Historically, the mechanical properties and function of the implant are the main concerns when the reconstructive device is being designed. 1,2 Osseointegration also takes place due to the balance between the osteoblastic and osteoclastic activity, representing the process of adaptation and formation for repair and function.…”

Section: Introductionmentioning

confidence: 99%

The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro

Jia

et al. 2015

RSC Adv.

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Achieving fast and long-term osseointegration is one of the major goals in dental implant design. Physicchemical surface modification is a key to osseointegration improvement. Two types of alkaline modifications, 1 M sodium bicarbonate and 0.05 M sodium hydroxide, were applied on the sand-blasting and acid etching (SLA) titanium surface. After the alkaline treatments, superhydrophilic SLA surfaces were produced. The mRNA expression level of IL-1b of Raw264.7 cells cultured on the sodium bicarbonate treated SLA surface was inhibited compared with SLA and sodium hydroxide treated surfaces, while MMP-9 expression on the sodium hydroxide treated SLA surface was increased with comparison to SLA and sodium bicarbonate treated surfaces. Cell adhesion of osteoblast-like MG63 cells on surfaces with alkaline treatments were moderately more pronounced than that on the SLA surface. With comparison to SLA surface, the proliferation of MG63 cells was decreased, while the alkaline phosphatase (ALP) activity was enhanced on the sodium bicarbonate treated SLA surface after 3 days. An increased mRNA expression level of integrin a v of MG63 cells were observed on the alkali treated surfaces compared with the SLA surface. Integrin b 1 , osteocalcin (OCN) and bone morphogenetic protein-2 (BMP-2) were enhanced on the sodium bicarbonate treated SLA surface when compared to the SLA surface. The results imply that the inflammation-related gene expression of macrophage cells is changed on sodium hydroxide and sodium bicarbonate treated SLA surfaces; the early adhesion of osteoblast-like cells is enhanced by both alkaline treatments, while the osteogenic differentiation is improved on sodium bicarbonate treated surface.

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Osseointegration—Molecular events at the bone–implant interface: A review

Cited by 44 publications

References 37 publications

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Titania Nanotubes for Local Drug Delivery from Implant Surfaces

The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro

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